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- W2950499832 abstract "Background: Primary central nervous system lymphoma(PCNSL)is a highly aggressive form of lymphoma with poor clinical outcomes and lack of a standard treatment regimen. Aims: To explore the methods of treatment in PCNSL. Methods: Patients aged 18-60 years with newly diagnosised PCNSL are treated with MTX+CDOD (Cyclophosphamide 750 mg/m2 d1, Doxorubicin HCl 40 mg/m2 d1, Vindesine 4 mg d1, dexamethasone 10 mg d1-5, MTX 3 g/m2 d2) /MTX+HD-Ara-C (cytarabine 1.5 g/m2 q12 h d1-2, methotrexate 3 g/m2 d3) Alternative chemotherapy for 6 total cycles, whose response evaluation is more than partial remission(PR) then sequentially with ASCT. Results: From June 2017 to June 2018, 17 patients in five hospitals in southwest China accepted CDOD+MTX/HD-Ara-C+MTX Alternative chemotherapy sequent with ASCT. The median age was 46(32-57), 9 males and 8 females, among the pathological types, 1 patient was high-grade B-cell lymphoma, and the rest were DLBCL. Two patients dropped out of the study at course 4 and 5 of chemotherapy for disease progression, the remaining 15 patients received ASCT sequentially. Before transplantation, 12 patients reached complete remission(CR), 3 patients reached PR. The overall remission rate of chemotherapy is 88%. After transplantation, 13 patients CR, 2 patients still PR. By January 2019, the median follow-up time was 9 months(7-12), two patients relapsed and one patient died after recurrence, the median overall survival(OS) is 9months9(7-12), and the median progression free survival(PFS) is also 9 months9(6-12). No grade III/IV hematological or non-hematological adverse events were observed. Summary/Conclusion: Our preliminary results show that RCDOD+MTX/HD-Ara-C+MTX alternative chemotherapy sequent with ASCT is a effective and safe trentment for PCNSL, and long-term follow-up is needed to further evaluate its efficacy." @default.
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- W2950499832 date "2019-06-01" @default.
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- W2950499832 title "PB1811 A SINGLE ARM MULTICENTENNIAL CLINICAL STUDY IN THE TREATMENT OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA(PCNSL) WITH ALTERNATIVE CHEMOTHERAPY SEQUENT WITH AUTOLOGOUS TRANSPLANTATION" @default.
- W2950499832 doi "https://doi.org/10.1097/01.hs9.0000565748.59755.ac" @default.
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