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- W2950500116 abstract "In mice, memory B (Bmem) cells can be divided into two subpopulations: CD80hi Bmem cells, which preferentially differentiate into plasma cells; and CD80lo Bmem cells, which become germinal center (GC) B cells during a recall response. We demonstrate that these distinct responses can be B-cell-intrinsic and essentially independent of B-cell receptor (BCR) isotypes. Furthermore, we find that the development of CD80hi Bmem cells in the primary immune response requires follicular helper T cells, a relatively strong CD40 signal and a high-affinity BCR on B cells, whereas the development of CD80lo Bmem cells does not. Quantitative differences in CD40 stimulation were enough to recapitulate the distinct B cell fate decisions in an in vitro culture system. The quantity of CD40 signaling appears to be translated into NF-κB activation, followed by BATF upregulation that promotes Bmem cell differentiation from GC B cells." @default.
- W2950500116 created "2019-06-27" @default.
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- W2950500116 date "2019-06-21" @default.
- W2950500116 modified "2023-09-24" @default.
- W2950500116 title "The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets" @default.
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- W2950500116 doi "https://doi.org/10.7554/elife.44245" @default.
- W2950500116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6636905" @default.
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