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- W2950508907 abstract "Enantiomerically pure precursors of β-blockers (propranolol, alprenolol and 1-(isopropylamino)-3-p-methoxy-phenoxy-2-propanol) were synthesized. Key step is the lipase-catalyzed kinetic resolution of rac-3-hydroxy esters either by O-acylation using vinyl acetate or by hydrolysis of the ester group. Both approaches were highly enantioselective (> 95 %ee) with E-values > 150 using lipase from Pseudomonas cepacia. The formal synthesis of (−)-(S)-propranolol was developed in subsequent steps." @default.
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- W2950508907 date "1996-07-01" @default.
- W2950508907 modified "2023-09-27" @default.
- W2950508907 title "Chemoenzymatic route to β-blockers via 3-hydroxy esters" @default.
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- W2950508907 doi "https://doi.org/10.1016/0957-4166(96)00243-1" @default.
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