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• W2950509008 startingPage "610" @default.
• W2950509008 abstract "Catatonia is a psychomotor syndrome associated with several psychiatric and medical conditions. Psychomotor signs range from stupor to agitation, and include pathognomonic features such as verbigeration and waxy flexibility. Disturbances of volition led to the classification of catatonia as a subtype of schizophrenia, but changes in nosology now recognise the high prevalence in mood disorders, overlap with delirium, and comorbidity with medical conditions. Initial psychometric studies have revealed three behavioural factors, but the structure of catatonia is still unknown. Evidence from brain imaging studies of patients with psychotic disorders indicates increased neural activity in premotor areas in patients with hypokinetic catatonia. However, whether this localised hyperactivity is due to corticocortical inhibition or excess activity of inhibitory corticobasal ganglia loops is unclear. Current treatment of catatonia relies on benzodiazepines and electroconvulsive therapy—both effective, yet unspecific in their modes of action. Longitudinal research and treatment studies, with neuroimaging and brain stimulation techniques, are needed to advance our understanding of catatonia." @default.
• W2950509008 created "2019-06-27" @default.
• W2950509008 creator A5017882622 @default.
• W2950509008 creator A5039198415 @default.
• W2950509008 creator A5054901878 @default.
• W2950509008 creator A5087337427 @default.
• W2950509008 date "2019-07-01" @default.
• W2950509008 modified "2023-10-14" @default.
• W2950509008 title "Structure and neural mechanisms of catatonia" @default.
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