Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950526259> ?p ?o ?g. }
- W2950526259 endingPage "186" @default.
- W2950526259 startingPage "186" @default.
- W2950526259 abstract "Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds. In this context, the chemical composition of three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration or ultrasound-assisted method (fresh and dried leaves) was investigated. A guided fractionation obtained three main components: pinocembrin, glabranin and licoflavanone. All the extracts showed similar antioxidant properties, evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH) or 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt (ABTS) assay, while, among the isolated compounds, licoflavanone exhibited the best antioxidant activity. The anti-inflammatory activity of the extracts and the purified compounds was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Extract C and licoflavanone showed a good anti-inflammatory activity without affecting cell viability, as they decreased nitrite levels even when used at 12.5 μg/mL (p < 0.005) and 50 μM concentration (p < 0.001), respectively. Interestingly, licoflavanone markedly decreased pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels (p < 0.001). A modulation of nuclear factor kappa B/mitogen-activated protein kinases (NF-kB/MAPK) pathway underlay such behavior, highlighting the potential of this natural compound as a new scaffold in anti-inflammatory drug research." @default.
- W2950526259 created "2019-06-27" @default.
- W2950526259 creator A5002681020 @default.
- W2950526259 creator A5014579151 @default.
- W2950526259 creator A5021882845 @default.
- W2950526259 creator A5028328541 @default.
- W2950526259 creator A5035655856 @default.
- W2950526259 creator A5050767033 @default.
- W2950526259 creator A5075093036 @default.
- W2950526259 creator A5082275152 @default.
- W2950526259 creator A5084971412 @default.
- W2950526259 creator A5086535821 @default.
- W2950526259 date "2019-06-20" @default.
- W2950526259 modified "2023-10-01" @default.
- W2950526259 title "Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway" @default.
- W2950526259 cites W1959511032 @default.
- W2950526259 cites W1982029299 @default.
- W2950526259 cites W1984658969 @default.
- W2950526259 cites W1986635189 @default.
- W2950526259 cites W1991378513 @default.
- W2950526259 cites W1999177172 @default.
- W2950526259 cites W2028138508 @default.
- W2950526259 cites W2032955209 @default.
- W2950526259 cites W2043460095 @default.
- W2950526259 cites W2044195489 @default.
- W2950526259 cites W2049788350 @default.
- W2950526259 cites W2056131072 @default.
- W2950526259 cites W2058236221 @default.
- W2950526259 cites W2064091164 @default.
- W2950526259 cites W2067025937 @default.
- W2950526259 cites W2068359668 @default.
- W2950526259 cites W2072004151 @default.
- W2950526259 cites W2085258335 @default.
- W2950526259 cites W2089842365 @default.
- W2950526259 cites W2166714220 @default.
- W2950526259 cites W2282124923 @default.
- W2950526259 cites W2289706667 @default.
- W2950526259 cites W2406900091 @default.
- W2950526259 cites W2498439654 @default.
- W2950526259 cites W2521738447 @default.
- W2950526259 cites W2562834111 @default.
- W2950526259 cites W2564342551 @default.
- W2950526259 cites W2751954879 @default.
- W2950526259 cites W2785091318 @default.
- W2950526259 cites W2789509184 @default.
- W2950526259 cites W2791918188 @default.
- W2950526259 cites W2793458035 @default.
- W2950526259 cites W2807372557 @default.
- W2950526259 cites W2808335801 @default.
- W2950526259 cites W2809637461 @default.
- W2950526259 cites W2886070608 @default.
- W2950526259 cites W2888180412 @default.
- W2950526259 cites W2903059252 @default.
- W2950526259 cites W2913315260 @default.
- W2950526259 cites W2913798745 @default.
- W2950526259 cites W2914786870 @default.
- W2950526259 cites W2916815521 @default.
- W2950526259 cites W2931101736 @default.
- W2950526259 doi "https://doi.org/10.3390/antiox8060186" @default.
- W2950526259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6616548" @default.
- W2950526259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31226797" @default.
- W2950526259 hasPublicationYear "2019" @default.
- W2950526259 type Work @default.
- W2950526259 sameAs 2950526259 @default.
- W2950526259 citedByCount "86" @default.
- W2950526259 countsByYear W29505262592019 @default.
- W2950526259 countsByYear W29505262592020 @default.
- W2950526259 countsByYear W29505262592021 @default.
- W2950526259 countsByYear W29505262592022 @default.
- W2950526259 countsByYear W29505262592023 @default.
- W2950526259 crossrefType "journal-article" @default.
- W2950526259 hasAuthorship W2950526259A5002681020 @default.
- W2950526259 hasAuthorship W2950526259A5014579151 @default.
- W2950526259 hasAuthorship W2950526259A5021882845 @default.
- W2950526259 hasAuthorship W2950526259A5028328541 @default.
- W2950526259 hasAuthorship W2950526259A5035655856 @default.
- W2950526259 hasAuthorship W2950526259A5050767033 @default.
- W2950526259 hasAuthorship W2950526259A5075093036 @default.
- W2950526259 hasAuthorship W2950526259A5082275152 @default.
- W2950526259 hasAuthorship W2950526259A5084971412 @default.
- W2950526259 hasAuthorship W2950526259A5086535821 @default.
- W2950526259 hasBestOaLocation W29505262591 @default.
- W2950526259 hasConcept C184235292 @default.
- W2950526259 hasConcept C185592680 @default.
- W2950526259 hasConcept C190283241 @default.
- W2950526259 hasConcept C2778004101 @default.
- W2950526259 hasConcept C2781031786 @default.
- W2950526259 hasConcept C2781401929 @default.
- W2950526259 hasConcept C53227056 @default.
- W2950526259 hasConcept C55493867 @default.
- W2950526259 hasConcept C556039675 @default.
- W2950526259 hasConcept C57074206 @default.
- W2950526259 hasConcept C71924100 @default.
- W2950526259 hasConcept C86803240 @default.
- W2950526259 hasConcept C98274493 @default.
- W2950526259 hasConceptScore W2950526259C184235292 @default.
- W2950526259 hasConceptScore W2950526259C185592680 @default.
- W2950526259 hasConceptScore W2950526259C190283241 @default.