FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950531837> ?p ?o ?g. }

• W2950531837 abstract "Understanding the nature of epileptic state transitions remains a major goal for epilepsy research. Simple in vitro models offer unique experimental opportunities, which we exploit to show that such transitions can arise from shifts in the ictal source of the activity. These transitions reflect the fact that cortical territories differ both in the type of epileptiform activity they can sustain, and their susceptibility to drug manipulation. In the zero Mg2+ model, the earliest epileptiform activity is restricted to neocortical and entorhinal networks. Hippocampal bursting only starts much later, and triggers a marked transition in neo-/entorhinal cortical activity. Thereafter, the hippocampal activity acts as a pacemaker, entraining the other territories to their discharge pattern. This entrainment persists following transection of the major axonal pathways between hippocampus and cortex, indicating that it can be mediated through a non-synaptic route. Neuronal discharges are associated with large rises in extracellular [K+], but we show that these are very localised, and therefore are not the means of entraining distant cortical areas. We conclude instead that the entrainment occurs through weak field effects distant from the pacemaker, but which are highly effective at recruiting other brain territories that are already hyperexcitable. The hippocampal epileptiform activity appears unusually susceptible to drugs that impact on K+ conductances. These findings demonstrate that the local circuitry gives rise to stereotypical epileptic activity patterns, but these are also influenced by both synaptic and non-synaptic long-range effects. Our results have important implications for our understanding of epileptic propagation, and anti-epileptic drug action." @default.
• W2950531837 created "2019-06-27" @default.
• W2950531837 creator A5034288979 @default.
• W2950531837 creator A5042239715 @default.
• W2950531837 creator A5056097437 @default.
• W2950531837 date "2018-10-05" @default.
• W2950531837 modified "2023-09-26" @default.
• W2950531837 title "Region-specific differences and areal interactions underlying transitions in epileptiform activity" @default.
• W2950531837 cites W1483455478 @default.
• W2950531837 cites W1501375812 @default.
• W2950531837 cites W1810589619 @default.
• W2950531837 cites W1828807460 @default.
• W2950531837 cites W1965625137 @default.
• W2950531837 cites W1966474984 @default.
• W2950531837 cites W1966603478 @default.
• W2950531837 cites W1969090298 @default.
• W2950531837 cites W1970604942 @default.
• W2950531837 cites W1977278938 @default.
• W2950531837 cites W1977873342 @default.
• W2950531837 cites W1986040386 @default.
• W2950531837 cites W1988764473 @default.
• W2950531837 cites W1997693301 @default.
• W2950531837 cites W2003029317 @default.
• W2950531837 cites W2004554357 @default.
• W2950531837 cites W2005155116 @default.
• W2950531837 cites W2008263877 @default.
• W2950531837 cites W2015297801 @default.
• W2950531837 cites W2015378456 @default.
• W2950531837 cites W2015478157 @default.
• W2950531837 cites W2018213090 @default.
• W2950531837 cites W2028756092 @default.
• W2950531837 cites W2031004922 @default.
• W2950531837 cites W2033271120 @default.
• W2950531837 cites W2048814015 @default.
• W2950531837 cites W2051868293 @default.
• W2950531837 cites W2053696902 @default.
• W2950531837 cites W2061547023 @default.
• W2950531837 cites W2063091823 @default.
• W2950531837 cites W2065882361 @default.
• W2950531837 cites W2066765190 @default.
• W2950531837 cites W2078156409 @default.
• W2950531837 cites W2087199924 @default.
• W2950531837 cites W2090063036 @default.
• W2950531837 cites W2095881782 @default.
• W2950531837 cites W2105003565 @default.
• W2950531837 cites W2105423985 @default.
• W2950531837 cites W2125701988 @default.
• W2950531837 cites W2132718296 @default.
• W2950531837 cites W2142123695 @default.
• W2950531837 cites W2147427684 @default.
• W2950531837 cites W2150497419 @default.
• W2950531837 cites W2157338202 @default.
• W2950531837 cites W2157874245 @default.
• W2950531837 cites W2160607236 @default.
• W2950531837 cites W2282674293 @default.
• W2950531837 cites W2319172225 @default.
• W2950531837 cites W2339679489 @default.
• W2950531837 cites W2604172498 @default.
• W2950531837 cites W2786209162 @default.
• W2950531837 cites W2802019646 @default.
• W2950531837 cites W4210244804 @default.
• W2950531837 cites W828310207 @default.
• W2950531837 doi "https://doi.org/10.1101/435156" @default.
• W2950531837 hasPublicationYear "2018" @default.
• W2950531837 type Work @default.
• W2950531837 sameAs 2950531837 @default.
• W2950531837 citedByCount "2" @default.
• W2950531837 countsByYear W29505318372018 @default.
• W2950531837 countsByYear W29505318372019 @default.
• W2950531837 crossrefType "posted-content" @default.
• W2950531837 hasAuthorship W2950531837A5034288979 @default.
• W2950531837 hasAuthorship W2950531837A5042239715 @default.
• W2950531837 hasAuthorship W2950531837A5056097437 @default.
• W2950531837 hasBestOaLocation W29505318371 @default.
• W2950531837 hasConcept C121332964 @default.
• W2950531837 hasConcept C135343436 @default.
• W2950531837 hasConcept C139992725 @default.
• W2950531837 hasConcept C148762608 @default.
• W2950531837 hasConcept C169760540 @default.
• W2950531837 hasConcept C17755696 @default.
• W2950531837 hasConcept C195221683 @default.
• W2950531837 hasConcept C24890656 @default.
• W2950531837 hasConcept C2778186239 @default.
• W2950531837 hasConcept C2780715579 @default.
• W2950531837 hasConcept C2781161787 @default.
• W2950531837 hasConcept C74254510 @default.
• W2950531837 hasConcept C86803240 @default.
• W2950531837 hasConceptScore W2950531837C121332964 @default.
• W2950531837 hasConceptScore W2950531837C135343436 @default.
• W2950531837 hasConceptScore W2950531837C139992725 @default.
• W2950531837 hasConceptScore W2950531837C148762608 @default.
• W2950531837 hasConceptScore W2950531837C169760540 @default.
• W2950531837 hasConceptScore W2950531837C17755696 @default.
• W2950531837 hasConceptScore W2950531837C195221683 @default.
• W2950531837 hasConceptScore W2950531837C24890656 @default.
• W2950531837 hasConceptScore W2950531837C2778186239 @default.
• W2950531837 hasConceptScore W2950531837C2780715579 @default.
• W2950531837 hasConceptScore W2950531837C2781161787 @default.
• W2950531837 hasConceptScore W2950531837C74254510 @default.
• W2950531837 hasConceptScore W2950531837C86803240 @default.

• next