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- W2950533246 abstract "We have developed two novel series of tetrasubstituted pyrazoles, embodying 1,3-diaryl-4,5-dialkyl or 3,5-diaryl-1,4-dialkyl substitution patterns. The scope of a regioselective method, developed by us earlier, was expanded to allow the synthesis of the first series of these tetrasubstituted pyrazoles directly from α,β-unsaturated ketones. The binding affinity of some of these pyrazoles for the estrogen receptor (ER) subtypes ERα and ERβ is very high, and the overall affinity pattern suggests the importance of three phenol substituents for high affinity, ERα-selective binding." @default.
- W2950533246 created "2019-06-27" @default.
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- W2950533246 date "2010-05-20" @default.
- W2950533246 modified "2023-09-26" @default.
- W2950533246 title "ChemInform Abstract: Diaryl-Dialkyl-Substituted Pyrazoles: Regioselective Synthesis and Binding Affinity for the Estrogen Receptor." @default.
- W2950533246 cites W1979314388 @default.
- W2950533246 doi "https://doi.org/10.1002/chin.200230147" @default.
- W2950533246 hasPublicationYear "2010" @default.
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