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- W2950543777 abstract "Preparation of 5-amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones (5a-h) and 7-amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5(4H)-ones (8a-n) was accomplished by nitrosative cyclization of the desired 2,5,6-triaminopyrimidine (2a-h) and 4,5,6-triaminopyrimidine derivatives (7a-n) with nitrous acid, respectively. Compounds 5a-h were also prepared by nucleophilic replacement of the methylthio group of 5-methylthio-1H-[1,2,3]triazolo[4,5-d]-pyrimidin-7(6H)-one (4) by appropriate amines. Similarly, some 7-amino derivatives (lOa-i) were synthesized by replacement of the thiol groups of the 7-thiol derivative (9) by appropriate amines. Antitumor and antiviral activities of the synthesized compounds were evaluated in vitro." @default.
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- W2950543777 date "2008-01-01" @default.
- W2950543777 modified "2023-09-26" @default.
- W2950543777 title "Design, Synthesis and Evaluation of Antitumor and Antiviral Activities of 5-Amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones (8-Azaguanines) and 7-Amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5(4H)-ones (8-Azaisoguanines)" @default.
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- W2950543777 doi "https://doi.org/10.3987/com-08-s(n)50" @default.
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