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• W2950552917 abstract "The striatum is an input structure of the basal ganglia implicated in several time-dependent functions including reinforcement learning, decision making, and interval timing. To determine whether striatal ensembles drive subjects' judgments of duration, we manipulated and recorded from striatal neurons in rats performing a duration categorization psychophysical task. We found that the dynamics of striatal neurons predicted duration judgments, and that simultaneously recorded ensembles could judge duration as well as the animal. Furthermore, striatal neurons were necessary for duration judgments, as muscimol infusions produced a specific impairment in animals' duration sensitivity. Lastly, we show that time as encoded by striatal populations ran faster or slower when rats judged a duration as longer or shorter, respectively. These results demonstrate that the speed with which striatal population state changes supports the fundamental ability of animals to judge the passage of time." @default.
• W2950552917 created "2019-06-27" @default.
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• W2950552917 date "2015-06-15" @default.
• W2950552917 modified "2023-09-23" @default.
• W2950552917 title "Striatal dynamics explain duration judgments" @default.
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• W2950552917 doi "https://doi.org/10.1101/020883" @default.
• W2950552917 hasPublicationYear "2015" @default.
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