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• W2950553863 endingPage "488" @default.
• W2950553863 startingPage "470" @default.
• W2950553863 abstract "Colorectal resection is associated with 3-5 wk long elevations in the plasma levels of at least 11 proangiogenic proteins that may stimulate tumor angiogenesis post-surgery. The increases during the first week after surgery may be related to the acute inflammatory response; the cause(s) of the week 2-5 increases is unknown. The wounds are a possible source because of the important role that angiogenesis plays in the healing process. The main hypothesis of the study is that wound fluid levels of the proteins studied will be elevated well beyond plasma levels which, in turn, are elevated from preoperative baseline levels.To determine plasma and wound fluid levels of 8 proangiogenic proteins after colorectal resection for cancer and benign pathology.Blood and wound fluid samples were taken simultaneously on postoperative (postop) day 1, 3, and later time points until wound drain removal in 35 colorectal cancer patients and 31 benign disease patients undergoing colorectal resection in whom closed wound drains had been placed in either the pelvis or the subcutaneous space of the abdominal incision. Postop plasma levels were compared to preop plasma and postop wound fluid levels (separate analyses for cancer and benign groups).Sixty-six colorectal disease patients were studied (35 cancer, 31 benign pathology). Most patients underwent minimally invasive surgery (open surgery in 11% of cancer and 6% of benign patients). The majority in the cancer group had rectal resections while in the benign group sigmoid or right colectomy predominated. Plasma levels of all 8 proteins were significantly elevated from baseline (P < 0.05) at all post-operative time points in the cancer group and at 90% of time points (29/32) in the benign group. Wound levels of all 8 proteins were 3-106 times higher (P < 0.05) than plasma levels at 87-90 percent of postop time points; of note, wound levels were more than 10 times higher at 47-50% of time points.Plasma protein levels were elevated for 3 weeks after surgery; wound fluid levels were much greater than corresponding blood levels. Healing wounds may be the source of the plasma increases." @default.
• W2950553863 created "2019-06-27" @default.
• W2950553863 creator A5004845960 @default.
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• W2950553863 creator A5088930540 @default.
• W2950553863 creator A5090943819 @default.
• W2950553863 date "2019-06-15" @default.
• W2950553863 modified "2023-10-16" @default.
• W2950553863 title "Plasma and wound fluid levels of eight proangiogenic proteins are elevated after colorectal resection" @default.
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• W2950553863 doi "https://doi.org/10.4251/wjgo.v11.i6.470" @default.
• W2950553863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6580318" @default.
• W2950553863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31236198" @default.
• W2950553863 hasPublicationYear "2019" @default.

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