Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950557629> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2950557629 abstract "The complex genetic programs of eukaryotic cells are often regulated by key transcription factors occupying or clearing out of a large number of genomic locations. Orchestrating the residence times of these factors is therefore important for the well organized functioning of a large network. The classic models of genetic switches sidestep this timing issue by assuming the binding of transcription factors to be governed entirely by thermodynamic protein-DNA affinities. Here we show that relying on passive thermodynamics and random release times can lead to a for master genes that broadcast their signals to a large number of binding sites. We demonstrate that this time-scale crisis for clearance in a large broadcasting network can be resolved by actively regulating residence times through molecular stripping. We illustrate these ideas by studying a model of the stochastic dynamics of the genetic network of the central eukaryotic master regulator NFκB which broadcasts its signals to many downstream genes that regulate immune response, apoptosis, etc." @default.
- W2950557629 created "2019-06-27" @default.
- W2950557629 creator A5009982949 @default.
- W2950557629 creator A5023161837 @default.
- W2950557629 date "2017-03-16" @default.
- W2950557629 modified "2023-09-24" @default.
- W2950557629 title "Stochastic dynamics of genetic broadcasting networks." @default.
- W2950557629 hasPublicationYear "2017" @default.
- W2950557629 type Work @default.
- W2950557629 sameAs 2950557629 @default.
- W2950557629 citedByCount "0" @default.
- W2950557629 crossrefType "journal-article" @default.
- W2950557629 hasAuthorship W2950557629A5009982949 @default.
- W2950557629 hasAuthorship W2950557629A5023161837 @default.
- W2950557629 hasConcept C104317684 @default.
- W2950557629 hasConcept C110157686 @default.
- W2950557629 hasConcept C121332964 @default.
- W2950557629 hasConcept C121864883 @default.
- W2950557629 hasConcept C2984125019 @default.
- W2950557629 hasConcept C2986044853 @default.
- W2950557629 hasConcept C3017607883 @default.
- W2950557629 hasConcept C31258907 @default.
- W2950557629 hasConcept C41008148 @default.
- W2950557629 hasConcept C54355233 @default.
- W2950557629 hasConcept C70721500 @default.
- W2950557629 hasConcept C86339819 @default.
- W2950557629 hasConcept C86803240 @default.
- W2950557629 hasConceptScore W2950557629C104317684 @default.
- W2950557629 hasConceptScore W2950557629C110157686 @default.
- W2950557629 hasConceptScore W2950557629C121332964 @default.
- W2950557629 hasConceptScore W2950557629C121864883 @default.
- W2950557629 hasConceptScore W2950557629C2984125019 @default.
- W2950557629 hasConceptScore W2950557629C2986044853 @default.
- W2950557629 hasConceptScore W2950557629C3017607883 @default.
- W2950557629 hasConceptScore W2950557629C31258907 @default.
- W2950557629 hasConceptScore W2950557629C41008148 @default.
- W2950557629 hasConceptScore W2950557629C54355233 @default.
- W2950557629 hasConceptScore W2950557629C70721500 @default.
- W2950557629 hasConceptScore W2950557629C86339819 @default.
- W2950557629 hasConceptScore W2950557629C86803240 @default.
- W2950557629 hasLocation W29505576291 @default.
- W2950557629 hasOpenAccess W2950557629 @default.
- W2950557629 hasPrimaryLocation W29505576291 @default.
- W2950557629 hasRelatedWork W1831411565 @default.
- W2950557629 hasRelatedWork W1967728313 @default.
- W2950557629 hasRelatedWork W198810408 @default.
- W2950557629 hasRelatedWork W2011454854 @default.
- W2950557629 hasRelatedWork W2020469578 @default.
- W2950557629 hasRelatedWork W2022771091 @default.
- W2950557629 hasRelatedWork W2094879449 @default.
- W2950557629 hasRelatedWork W2134459671 @default.
- W2950557629 hasRelatedWork W2170408872 @default.
- W2950557629 hasRelatedWork W2233284171 @default.
- W2950557629 hasRelatedWork W2520982479 @default.
- W2950557629 hasRelatedWork W2761223651 @default.
- W2950557629 hasRelatedWork W2774133205 @default.
- W2950557629 hasRelatedWork W2783312669 @default.
- W2950557629 hasRelatedWork W2948840720 @default.
- W2950557629 hasRelatedWork W2952567353 @default.
- W2950557629 hasRelatedWork W2970908677 @default.
- W2950557629 hasRelatedWork W3201384416 @default.
- W2950557629 hasRelatedWork W846913356 @default.
- W2950557629 hasVolume "2017" @default.
- W2950557629 isParatext "false" @default.
- W2950557629 isRetracted "false" @default.
- W2950557629 magId "2950557629" @default.
- W2950557629 workType "article" @default.