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• W2950562964 endingPage "192" @default.
• W2950562964 startingPage "192" @default.
• W2950562964 abstract "High density lipoproteins (HDL) structure and function studies are needed to better understand the heterogeneous nature of the HDL particle, and its interaction with associated proteins such as apolipoprotein A-1 (ApoA-1), paraoxonase 1 (PON1) and the environment. Our study assesses the effects of acute inflammation on PON1 and HDL subclasses in post-surgical colorectal cancer patients. PON1 was measured kinetically through its arylesterase and lactonase activity and HDL sub-classes were measured using Quantimetrix Lipoprint® System. White blood cells (WBC) counts, c-reactive protein (CRP) and serum amyloid A (SAA) levels were also analyzed using standard techniques. Our findings show that baseline PON1 activity is lower in colorectal cancer patients and significant reductions are observed in the acute inflammatory state post-surgery. PON1 changes are also inversely related to inflammatory markers such as SAA and CRP. In addition, our preliminary findings show that small and intermediate HDL decreases post-op Day 1. In conclusion, our study demonstrates the effects of chronic and acute inflammation on PON1. Specifically, PON1 arylesterase and lactonase activity is lower in states of chronic inflammation and further decreased in the acute inflammatory state. Additionally, in our limited sample size, while changes in PON1 and HDL subclasses may be variable in the acute inflammatory period, small HDL decreased with a loss of PON1 activity in the subacute phase." @default.
• W2950562964 created "2019-06-27" @default.
• W2950562964 creator A5006682936 @default.
• W2950562964 creator A5025206192 @default.
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• W2950562964 date "2019-06-22" @default.
• W2950562964 modified "2023-09-25" @default.
• W2950562964 title "Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study" @default.
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• W2950562964 doi "https://doi.org/10.3390/antiox8060192" @default.
• W2950562964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6617233" @default.
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• W2950562964 hasPublicationYear "2019" @default.
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