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- W2950563265 abstract "Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has been expected as a new anticancer strategy. During our studies on search for bioactive natural products from various natural resources such as plants and microorganisms, we recently identified several natural products which exhibited activities related to TRAIL signaling. Dimeric sesquiterpenoids isolated from Zingiberaceous plant, Curcuma parviflora, showed enhancement activity of gene expression of TRAIL-receptor and TRAIL-receptor protein level. Several new isoflavone natural products, named brandisianins, were isolated from Leguminosaeous plant, Millettia brandisiana, by our screening study targeting TRAIL-receptor expression enhancement activity. A dihydroflavonol (BB1) that was extracted from Compositaeous plant, Blumea balsamifera, and fuligocandin B, a new anthranilylproline-indole alkaloid isolated from myxomycete were found to exhibit reversal effect of TRAIL resistance activity. © 2008 Wiley Periodicals, Inc. Med Res Rev, 28, No. 5, 688–714, 2008" @default.
- W2950563265 created "2019-06-27" @default.
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- W2950563265 date "2008-11-04" @default.
- W2950563265 modified "2023-09-26" @default.
- W2950563265 title "ChemInform Abstract: Studies on Search for Bioactive Natural Products Targeting TRAIL Signaling Leading to Tumor Cell Apoptosis" @default.
- W2950563265 cites W1983284232 @default.
- W2950563265 doi "https://doi.org/10.1002/chin.200845278" @default.
- W2950563265 hasPublicationYear "2008" @default.
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