FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950565500> ?p ?o ?g. }

• W2950565500 abstract "Background Kawasaki Disease (KD) is the second most common vasculitis in the pediatric population and the leading cause for pediatric acquired heart disease in developed countries. It is commonly diagnosed in the Mexican pediatric population, epidemiology in this country is not established, since cases are not usually reported to the healthcare system. The clinical features are quite variable, but diagnosis and prompt treatment will decrease morbidity and mortality. Coronary artery aneurysms are the most common complication, which represent the leading cause of acute coronary syndrome before 40 years of age. Recurrence of KD is estimated to be around 3% in Japanese patients and 1% in the United States, nevertheless, this data in Latin-American children is unknown. It usually affects patients before reaching 3 years old and within 2 years of the initial attack, presenting with an abrupt onset and higher complication rates, requiring aggressive workup, treatment and follow-up. Objectives To review an atypical presentation of KD and early recurrence in a 7-month-old female. Methods We present a 7-month-old female diagnosed with KD at 48 days old. She presented to the emergency unit with irritability, high and persistent fever and acholia. During workup, she was found with cholestasis and gallbladder hydrops. Negative CSF, blood and urine cultures were documented during hospitalization, and fulfilled the KD criteria. The cardiac ultrasound revealed coronary abnormalities: a RCA of 2.8mm (Z-Score +4.79), LCA of 3.3mm (Z-Score +5.69) and LAD of 2.4mm (Z-SCORE +4.25), which fit into classification 3 and 4, as small and medium aneurysms, according to AHA 2017. Immunoglobulin (2g/kg) and aspirin (80mg/kg) were administered and she was discharged 36 hours after the IVIg infusion, afebrile and with ambulatory follow-up, 30 days later the coronary abnormalities showed RCA of 2.0mm (Z-Score +2.3), LCA of 3.0mm (Z-Score +6), LAD 2.3mm (Z-Score +2.9). Six months later, she presented fever for 6 days, irritability and polymorphous rash. On physical exam BCGitis, non-suppurative conjunctivitis and pallor in hands and feet, elevated CRP and ESR, leukocytosis, thrombocytosis and sterile leukocyturia. Echocardiography reported RCA od 2.4mm (Z-Score +4.8), LCA of 3.1 (Z-Score +4.2) and LAD of 2.3mm (Z-Score +3.2), diagnosing KD recurrence, admitting the patient for IVIg and aspirin administration. Results The patient was treated with IVIg and aspirin. Follow-up by Cardiology determined improvement of Z-Scores. Recurrence occurred with worsening of the cardiac abnormalities. Cardiac prognosis is importantly affected due to the atypical age, vascular abnormalities and repeated vasculitic process. Rheumatologic consult should be considered since disease like Takayasu Arteritis, Polyarteritis Nosa and ADA2 deficiency need to be ruled out. Conclusion KD needs prompt diagnosis and treatment due to the potential consequences when delayed. Clinical suspicion is important due to the possible atypical presentation. As with this patient, age, gender and presentation are not exclusive. Despite adequate treatment, recurrence and worsening of the cardiac abnormalities occurred. Both KD events before 1 year old and with atypical presentations. Rheumatologic and cardiac follow-up need to be stringent through lifetime, to determine pharmacologic treatment, as ell as physical activity and reproductive counseling. References [1] McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, et al. Diagnosis, Treatment and Long-term Management of Kawasaki Disease: A scientific Statement for Health Professionals From the American Heart Association. Circulation2017;135(17):e927-e99. Disclosure of Interests None declared" @default.
• W2950565500 created "2019-06-27" @default.
• W2950565500 creator A5027445161 @default.
• W2950565500 creator A5032020785 @default.
• W2950565500 creator A5033065868 @default.
• W2950565500 creator A5085695674 @default.
• W2950565500 creator A5087857714 @default.
• W2950565500 date "2019-06-01" @default.
• W2950565500 modified "2023-10-02" @default.
• W2950565500 title "AB0957 ATYPICAL PRESENTATION AND EARLY RECURRENCE OF KAWASAKI DISEASE IN A FEMALE INFANT: CASE REPORT" @default.
• W2950565500 doi "https://doi.org/10.1136/annrheumdis-2019-eular.6490" @default.
• W2950565500 hasPublicationYear "2019" @default.
• W2950565500 type Work @default.
• W2950565500 sameAs 2950565500 @default.
• W2950565500 citedByCount "0" @default.
• W2950565500 crossrefType "proceedings-article" @default.
• W2950565500 hasAuthorship W2950565500A5027445161 @default.
• W2950565500 hasAuthorship W2950565500A5032020785 @default.
• W2950565500 hasAuthorship W2950565500A5033065868 @default.
• W2950565500 hasAuthorship W2950565500A5085695674 @default.
• W2950565500 hasAuthorship W2950565500A5087857714 @default.
• W2950565500 hasBestOaLocation W29505655001 @default.
• W2950565500 hasConcept C107130276 @default.
• W2950565500 hasConcept C126322002 @default.
• W2950565500 hasConcept C141071460 @default.
• W2950565500 hasConcept C187212893 @default.
• W2950565500 hasConcept C2776820930 @default.
• W2950565500 hasConcept C2778562196 @default.
• W2950565500 hasConcept C2780820931 @default.
• W2950565500 hasConcept C2781423770 @default.
• W2950565500 hasConcept C2908647359 @default.
• W2950565500 hasConcept C71924100 @default.
• W2950565500 hasConcept C81182388 @default.
• W2950565500 hasConcept C99454951 @default.
• W2950565500 hasConceptScore W2950565500C107130276 @default.
• W2950565500 hasConceptScore W2950565500C126322002 @default.
• W2950565500 hasConceptScore W2950565500C141071460 @default.
• W2950565500 hasConceptScore W2950565500C187212893 @default.
• W2950565500 hasConceptScore W2950565500C2776820930 @default.
• W2950565500 hasConceptScore W2950565500C2778562196 @default.
• W2950565500 hasConceptScore W2950565500C2780820931 @default.
• W2950565500 hasConceptScore W2950565500C2781423770 @default.
• W2950565500 hasConceptScore W2950565500C2908647359 @default.
• W2950565500 hasConceptScore W2950565500C71924100 @default.
• W2950565500 hasConceptScore W2950565500C81182388 @default.
• W2950565500 hasConceptScore W2950565500C99454951 @default.
• W2950565500 hasLocation W29505655001 @default.
• W2950565500 hasOpenAccess W2950565500 @default.
• W2950565500 hasPrimaryLocation W29505655001 @default.
• W2950565500 hasRelatedWork W1606291346 @default.
• W2950565500 hasRelatedWork W1801165806 @default.
• W2950565500 hasRelatedWork W1960344573 @default.
• W2950565500 hasRelatedWork W1980541537 @default.
• W2950565500 hasRelatedWork W2075814004 @default.
• W2950565500 hasRelatedWork W2083700104 @default.
• W2950565500 hasRelatedWork W2087457608 @default.
• W2950565500 hasRelatedWork W2327059442 @default.
• W2950565500 hasRelatedWork W2347626409 @default.
• W2950565500 hasRelatedWork W2409966357 @default.
• W2950565500 hasRelatedWork W2415300372 @default.
• W2950565500 hasRelatedWork W2743001930 @default.
• W2950565500 hasRelatedWork W2755024679 @default.
• W2950565500 hasRelatedWork W2757569548 @default.
• W2950565500 hasRelatedWork W2940686568 @default.
• W2950565500 hasRelatedWork W2983220122 @default.
• W2950565500 hasRelatedWork W3021812397 @default.
• W2950565500 hasRelatedWork W3029944788 @default.
• W2950565500 hasRelatedWork W3119117503 @default.
• W2950565500 hasRelatedWork W2017295978 @default.
• W2950565500 isParatext "false" @default.
• W2950565500 isRetracted "false" @default.
• W2950565500 magId "2950565500" @default.
• W2950565500 workType "article" @default.