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- W2950572182 abstract "To investigate the role of the amide group of (-)-indolactam-V (1) on PKC binding, we synthesized (-)-indothiolactam-V (2), a new thioamide analogue of 1, by microbial conversion using Streptomyces blastmyceticum. Compounds 2 and 1 showed similar binding affinities to conventional PKCs but 2 had lower affinities to novel PKCs, suggesting that novel PKCs recognize amide modifications more effectively than conventional PKCs." @default.
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- W2950572182 date "2000-12-05" @default.
- W2950572182 modified "2023-09-23" @default.
- W2950572182 title "ChemInform Abstract: Synthesis and PKC Isozyme Surrogate Binding of Indothiolactam-V, a New Thioamide Analogue of Tumor Promoting Indolactam-V." @default.
- W2950572182 cites W1971008674 @default.
- W2950572182 doi "https://doi.org/10.1002/chin.200049205" @default.
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