FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950573790> ?p ?o ?g. }

• W2950573790 abstract "ABSTRACT The Fusarium oxysporum species complex (FOSC) is a group of soil-borne pathogens causing severe disease in over one hundred plant hosts, while individual strains exhibit strong host specificity. Both chromosome transfer and comparative genomics experiments have demonstrated that lineage-specific (LS) chromosomes contribute to the host specific pathogenicity. However, little is known about the functional importance of genes encoded in these LS chromosomes. Focusing on signaling transduction, this study compared kinomes of 12 F. oxysporum isolates, including both plant and human pathogens and one non-pathogenic biocontrol strain, with seven additional publicly available ascomycete genomes. Overall, F. oxysporum kinomes are the largest, facilitated in part by the acquisitions of the LS chromosomes. The comparative study identified 99 kinases that are present in almost all examined fungal genomes, forming the core signaling network of ascomycete fungi. Compared to the conserved ascomycete kinome, the expansion of the F. oxysporum kinome occurs in several kinases families such as Histidine kinases that are involved in environmental signal sensing and TOR kinase that mediates cellular responses. Comparative kinome analysis suggests a convergent evolution that shapes individual F. oxysporum isolates with an enhanced and unique capacity for environmental perception and associated downstream responses. IMPORTANCE Isolates of F. oxysporum are adapted to survive a wide range of host and non-host conditions. In addition, F. oxysporum was recently recognized as the top emerging opportunistic fungal pathogen infecting immunocompromised humans. The sensory and response networks of these fungi undoubtedly play a fundamental role in establishing the adaptability of this group. We have examined the kinomes of 12 F. oxysporum isolates and highlighted kinase families that distinguish F. oxysporum from other fungi, as well as different isolates from one another. The amplification of kinases involved in environmental signal relay and regulating downstream cellular responses clearly sets Fusarium apart from other Ascomycetes. Though the function of many of these kinases is still unclear, their specific proliferation highlights them as a result of the evolutionary forces which have shaped this species complex, and clearly marks them as targets for exploitation in order to combat disease." @default.
• W2950573790 created "2019-06-27" @default.
• W2950573790 creator A5000586967 @default.
• W2950573790 creator A5026487938 @default.
• W2950573790 creator A5027785727 @default.
• W2950573790 creator A5052274142 @default.
• W2950573790 creator A5053438808 @default.
• W2950573790 creator A5073592065 @default.
• W2950573790 date "2018-04-25" @default.
• W2950573790 modified "2023-09-23" @default.
• W2950573790 title "Kinome expansion in theFusarium oxysporumspecies complex driven by accessary chromosomes" @default.
• W2950573790 cites W1823934166 @default.
• W2950573790 cites W1863994479 @default.
• W2950573790 cites W1950949146 @default.
• W2950573790 cites W1976368031 @default.
• W2950573790 cites W1980687541 @default.
• W2950573790 cites W1984344300 @default.
• W2950573790 cites W1997401532 @default.
• W2950573790 cites W1997962605 @default.
• W2950573790 cites W2002494513 @default.
• W2950573790 cites W2014741756 @default.
• W2950573790 cites W2015714994 @default.
• W2950573790 cites W2015794099 @default.
• W2950573790 cites W2016747889 @default.
• W2950573790 cites W2018517535 @default.
• W2950573790 cites W2023635099 @default.
• W2950573790 cites W2025591983 @default.
• W2950573790 cites W2030205108 @default.
• W2950573790 cites W2031870497 @default.
• W2950573790 cites W2032624656 @default.
• W2950573790 cites W2036201851 @default.
• W2950573790 cites W2041825338 @default.
• W2950573790 cites W2051928958 @default.
• W2950573790 cites W2060015604 @default.
• W2950573790 cites W2063013559 @default.
• W2950573790 cites W2080492298 @default.
• W2950573790 cites W2081358587 @default.
• W2950573790 cites W2083394284 @default.
• W2950573790 cites W2084934035 @default.
• W2950573790 cites W2085593164 @default.
• W2950573790 cites W2086317606 @default.
• W2950573790 cites W2089353165 @default.
• W2950573790 cites W2091030812 @default.
• W2950573790 cites W2098719212 @default.
• W2950573790 cites W2099521715 @default.
• W2950573790 cites W2100258698 @default.
• W2950573790 cites W2103801889 @default.
• W2950573790 cites W2104872953 @default.
• W2950573790 cites W2107093868 @default.
• W2950573790 cites W2107727333 @default.
• W2950573790 cites W2110905563 @default.
• W2950573790 cites W2111154506 @default.
• W2950573790 cites W2114104545 @default.
• W2950573790 cites W2118013428 @default.
• W2950573790 cites W2121944306 @default.
• W2950573790 cites W2122023734 @default.
• W2950573790 cites W2125098623 @default.
• W2950573790 cites W2125498284 @default.
• W2950573790 cites W2129153399 @default.
• W2950573790 cites W2131271579 @default.
• W2950573790 cites W2131675399 @default.
• W2950573790 cites W2131790368 @default.
• W2950573790 cites W2133347001 @default.
• W2950573790 cites W2140164333 @default.
• W2950573790 cites W2142160977 @default.
• W2950573790 cites W2143112776 @default.
• W2950573790 cites W2146512944 @default.
• W2950573790 cites W2147013899 @default.
• W2950573790 cites W2148450534 @default.
• W2950573790 cites W2152207030 @default.
• W2950573790 cites W2152914611 @default.
• W2950573790 cites W2153796242 @default.
• W2950573790 cites W2154459669 @default.
• W2950573790 cites W2157421521 @default.
• W2950573790 cites W2167493116 @default.
• W2950573790 cites W2168990146 @default.
• W2950573790 cites W2171468101 @default.
• W2950573790 cites W4251635246 @default.
• W2950573790 cites W757278325 @default.
• W2950573790 doi "https://doi.org/10.1101/308064" @default.
• W2950573790 hasPublicationYear "2018" @default.
• W2950573790 type Work @default.
• W2950573790 sameAs 2950573790 @default.
• W2950573790 citedByCount "0" @default.
• W2950573790 crossrefType "posted-content" @default.
• W2950573790 hasAuthorship W2950573790A5000586967 @default.
• W2950573790 hasAuthorship W2950573790A5026487938 @default.
• W2950573790 hasAuthorship W2950573790A5027785727 @default.
• W2950573790 hasAuthorship W2950573790A5052274142 @default.
• W2950573790 hasAuthorship W2950573790A5053438808 @default.
• W2950573790 hasAuthorship W2950573790A5073592065 @default.
• W2950573790 hasBestOaLocation W29505737901 @default.
• W2950573790 hasConcept C104317684 @default.
• W2950573790 hasConcept C105176652 @default.
• W2950573790 hasConcept C141231307 @default.
• W2950573790 hasConcept C189206191 @default.
• W2950573790 hasConcept C2776817793 @default.
• W2950573790 hasConcept C2779430813 @default.
• W2950573790 hasConcept C30481170 @default.
• W2950573790 hasConcept C54174078 @default.

• next