FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950573816> ?p ?o ?g. }

• W2950573816 abstract "The structure of molecular networks derives from dynamical processes on evolutionary time scales. For protein interaction networks, global statistical features of their structure can now be inferred consistently from several large-throughput datasets. Understanding the underlying evolutionary dynamics is crucial for discerning random parts of the network from biologically important properties shaped by natural selection. We present a detailed statistical analysis of the protein interactions in Saccharomyces cerevisiae based on several large-throughput datasets. Protein pairs resulting from gene duplications are used as tracers into the evolutionary past of the network. From this analysis, we infer rate estimates for two key evolutionary processes shaping the network: (i) gene duplications and (ii) gain and loss of interactions through mutations in existing proteins, which are referred to as link dynamics. Importantly, the link dynamics is asymmetric, i.e., the evolutionary steps are mutations in just one of the binding parters. The link turnover is shown to be much faster than gene duplications. According to this model, the link dynamics is the dominant evolutionary force shaping the statistical structure of the network, while the slower gene duplication dynamics mainly affects its size. Specifically, the model predicts (i) a broad distribution of the connectivities (i.e., the number of binding partners of a protein) and (ii) correlations between the connectivities of interacting proteins." @default.
• W2950573816 created "2019-06-27" @default.
• W2950573816 creator A5048286409 @default.
• W2950573816 creator A5061995455 @default.
• W2950573816 creator A5079730045 @default.
• W2950573816 date "2002-07-30" @default.
• W2950573816 modified "2023-09-27" @default.
• W2950573816 title "Structure and evolution of protein interaction networks: A statistical model for link dynamics and gene duplications" @default.
• W2950573816 cites W1641544182 @default.
• W2950573816 cites W1857738277 @default.
• W2950573816 cites W1977907334 @default.
• W2950573816 cites W1987510089 @default.
• W2950573816 cites W1995052256 @default.
• W2950573816 cites W2019591778 @default.
• W2950573816 cites W2031772330 @default.
• W2950573816 cites W2037036397 @default.
• W2950573816 cites W2040956707 @default.
• W2950573816 cites W2065304353 @default.
• W2950573816 cites W2074816168 @default.
• W2950573816 cites W2082367094 @default.
• W2950573816 cites W2084619201 @default.
• W2950573816 cites W2099982459 @default.
• W2950573816 cites W2113654464 @default.
• W2950573816 cites W2115475892 @default.
• W2950573816 cites W2117526623 @default.
• W2950573816 cites W2124637492 @default.
• W2950573816 cites W2130790725 @default.
• W2950573816 cites W2140611547 @default.
• W2950573816 cites W2140827816 @default.
• W2950573816 cites W2148606196 @default.
• W2950573816 cites W2156737316 @default.
• W2950573816 cites W2158714788 @default.
• W2950573816 cites W2167680767 @default.
• W2950573816 cites W2167869241 @default.
• W2950573816 cites W2763566443 @default.
• W2950573816 hasPublicationYear "2002" @default.
• W2950573816 type Work @default.
• W2950573816 sameAs 2950573816 @default.
• W2950573816 citedByCount "0" @default.
• W2950573816 crossrefType "posted-content" @default.
• W2950573816 hasAuthorship W2950573816A5048286409 @default.
• W2950573816 hasAuthorship W2950573816A5061995455 @default.
• W2950573816 hasAuthorship W2950573816A5079730045 @default.
• W2950573816 hasConcept C104317684 @default.
• W2950573816 hasConcept C144024400 @default.
• W2950573816 hasConcept C149923435 @default.
• W2950573816 hasConcept C150194340 @default.
• W2950573816 hasConcept C171578705 @default.
• W2950573816 hasConcept C2778753846 @default.
• W2950573816 hasConcept C28225019 @default.
• W2950573816 hasConcept C2908647359 @default.
• W2950573816 hasConcept C31258907 @default.
• W2950573816 hasConcept C41008148 @default.
• W2950573816 hasConcept C54355233 @default.
• W2950573816 hasConcept C55105296 @default.
• W2950573816 hasConcept C67339327 @default.
• W2950573816 hasConcept C70721500 @default.
• W2950573816 hasConcept C7602840 @default.
• W2950573816 hasConcept C78458016 @default.
• W2950573816 hasConcept C86803240 @default.
• W2950573816 hasConceptScore W2950573816C104317684 @default.
• W2950573816 hasConceptScore W2950573816C144024400 @default.
• W2950573816 hasConceptScore W2950573816C149923435 @default.
• W2950573816 hasConceptScore W2950573816C150194340 @default.
• W2950573816 hasConceptScore W2950573816C171578705 @default.
• W2950573816 hasConceptScore W2950573816C2778753846 @default.
• W2950573816 hasConceptScore W2950573816C28225019 @default.
• W2950573816 hasConceptScore W2950573816C2908647359 @default.
• W2950573816 hasConceptScore W2950573816C31258907 @default.
• W2950573816 hasConceptScore W2950573816C41008148 @default.
• W2950573816 hasConceptScore W2950573816C54355233 @default.
• W2950573816 hasConceptScore W2950573816C55105296 @default.
• W2950573816 hasConceptScore W2950573816C67339327 @default.
• W2950573816 hasConceptScore W2950573816C70721500 @default.
• W2950573816 hasConceptScore W2950573816C7602840 @default.
• W2950573816 hasConceptScore W2950573816C78458016 @default.
• W2950573816 hasConceptScore W2950573816C86803240 @default.
• W2950573816 hasLocation W29505738161 @default.
• W2950573816 hasOpenAccess W2950573816 @default.
• W2950573816 hasPrimaryLocation W29505738161 @default.
• W2950573816 hasRelatedWork W1486942243 @default.
• W2950573816 hasRelatedWork W1584744004 @default.
• W2950573816 hasRelatedWork W1908543963 @default.
• W2950573816 hasRelatedWork W1984209790 @default.
• W2950573816 hasRelatedWork W1996540294 @default.
• W2950573816 hasRelatedWork W2010057917 @default.
• W2950573816 hasRelatedWork W2023889921 @default.
• W2950573816 hasRelatedWork W2036336153 @default.
• W2950573816 hasRelatedWork W2038890185 @default.
• W2950573816 hasRelatedWork W2039648378 @default.
• W2950573816 hasRelatedWork W2041347955 @default.
• W2950573816 hasRelatedWork W2055552103 @default.
• W2950573816 hasRelatedWork W2088297372 @default.
• W2950573816 hasRelatedWork W2102562836 @default.
• W2950573816 hasRelatedWork W2110175019 @default.
• W2950573816 hasRelatedWork W2145823109 @default.
• W2950573816 hasRelatedWork W2388480705 @default.
• W2950573816 hasRelatedWork W2949698492 @default.
• W2950573816 hasRelatedWork W116867194 @default.
• W2950573816 hasRelatedWork W3150523789 @default.

• next