FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950578201> ?p ?o ?g. }

• W2950578201 endingPage "407" @default.
• W2950578201 startingPage "397" @default.
• W2950578201 abstract "Abstract Apoptosis occurs primarily in the blastocyst inner cell mass, cells of which go on to form the foetus. Apoptosis is likely to play a role in ensuring the genetic integrity of the foetus, yet little is known about its regulation. In this study, the role of the mouse gene, transformation-related protein 53 (Trp53) in the response of embryos to in vitro culture and environmentally induced DNA damage was investigated using embryos from a Trp53 knockout mouse model. In vivo-derived blastocysts were compared to control embryos X-irradiated at the two-cell stage and cultured to Day 5. An analysis of DNA by comet assay demonstrated that 1.5 Gy X-irradiation directly induced damage in cultured two-cell mouse embryos; this was correlated with retarded development to blastocyst stage and increased apoptosis at the blastocyst stage but not prior to this. Trp53 null embryos developed to blastocysts at a higher frequency and with higher cell numbers than wild-type embryos. Trp53 also mediates apoptosis in conditions of low levels of DNA damage, in vivo or in vitro in the absence of irradiation. However, following DNA damage induced by X-irradiation, apoptosis is induced by Trp53 independent as well as dependent mechanisms. These data suggest that Trp53 and apoptosis play important roles in normal mouse embryonic development both in vitro and in vivo and in response to DNA damage. Therefore, clinical ART practices that alter apoptosis in human embryos and/or select embryos for transfer, which potentially lack a functional Trp53 gene, need to be carefully considered." @default.
• W2950578201 created "2019-06-27" @default.
• W2950578201 creator A5003101926 @default.
• W2950578201 creator A5007353427 @default.
• W2950578201 creator A5031050575 @default.
• W2950578201 creator A5065773576 @default.
• W2950578201 date "2019-06-22" @default.
• W2950578201 modified "2023-10-16" @default.
• W2950578201 title "The role of Trp53 in the mouse embryonic response to DNA damage" @default.
• W2950578201 cites W1514759469 @default.
• W2950578201 cites W1782681677 @default.
• W2950578201 cites W1950488640 @default.
• W2950578201 cites W1965783915 @default.
• W2950578201 cites W1969044026 @default.
• W2950578201 cites W1974272543 @default.
• W2950578201 cites W1977707442 @default.
• W2950578201 cites W1989768423 @default.
• W2950578201 cites W1992667313 @default.
• W2950578201 cites W2001562379 @default.
• W2950578201 cites W2009864596 @default.
• W2950578201 cites W2015565010 @default.
• W2950578201 cites W2023550300 @default.
• W2950578201 cites W2024480685 @default.
• W2950578201 cites W2025233095 @default.
• W2950578201 cites W2032806930 @default.
• W2950578201 cites W2045872949 @default.
• W2950578201 cites W2046244754 @default.
• W2950578201 cites W2074314238 @default.
• W2950578201 cites W2077726871 @default.
• W2950578201 cites W2079706840 @default.
• W2950578201 cites W2090643419 @default.
• W2950578201 cites W2097651998 @default.
• W2950578201 cites W2101758786 @default.
• W2950578201 cites W2102698801 @default.
• W2950578201 cites W2107098688 @default.
• W2950578201 cites W2115710268 @default.
• W2950578201 cites W2116574982 @default.
• W2950578201 cites W2117182829 @default.
• W2950578201 cites W2118928928 @default.
• W2950578201 cites W2120390855 @default.
• W2950578201 cites W2121463472 @default.
• W2950578201 cites W2121510117 @default.
• W2950578201 cites W2126679757 @default.
• W2950578201 cites W2129395899 @default.
• W2950578201 cites W2129905922 @default.
• W2950578201 cites W2142038691 @default.
• W2950578201 cites W2142452362 @default.
• W2950578201 cites W2147501302 @default.
• W2950578201 cites W2148050967 @default.
• W2950578201 cites W2149345712 @default.
• W2950578201 cites W2156802994 @default.
• W2950578201 cites W2162440076 @default.
• W2950578201 cites W2164559377 @default.
• W2950578201 cites W2167619669 @default.
• W2950578201 cites W2168139864 @default.
• W2950578201 cites W2169550093 @default.
• W2950578201 cites W2322017433 @default.
• W2950578201 cites W2329563304 @default.
• W2950578201 cites W2335035341 @default.
• W2950578201 cites W2582057979 @default.
• W2950578201 cites W2773949516 @default.
• W2950578201 cites W2809081803 @default.
• W2950578201 cites W2809514303 @default.
• W2950578201 cites W2904189731 @default.
• W2950578201 cites W2915505354 @default.
• W2950578201 cites W4248748009 @default.
• W2950578201 cites W4299636312 @default.
• W2950578201 cites W90002144 @default.
• W2950578201 doi "https://doi.org/10.1093/molehr/gaz029" @default.
• W2950578201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31227838" @default.
• W2950578201 hasPublicationYear "2019" @default.
• W2950578201 type Work @default.
• W2950578201 sameAs 2950578201 @default.
• W2950578201 citedByCount "2" @default.
• W2950578201 countsByYear W29505782012021 @default.
• W2950578201 countsByYear W29505782012022 @default.
• W2950578201 crossrefType "journal-article" @default.
• W2950578201 hasAuthorship W2950578201A5003101926 @default.
• W2950578201 hasAuthorship W2950578201A5007353427 @default.
• W2950578201 hasAuthorship W2950578201A5031050575 @default.
• W2950578201 hasAuthorship W2950578201A5065773576 @default.
• W2950578201 hasBestOaLocation W29505782012 @default.
• W2950578201 hasConcept C104317684 @default.
• W2950578201 hasConcept C134935766 @default.
• W2950578201 hasConcept C143425029 @default.
• W2950578201 hasConcept C145103041 @default.
• W2950578201 hasConcept C153911025 @default.
• W2950578201 hasConcept C159399396 @default.
• W2950578201 hasConcept C190283241 @default.
• W2950578201 hasConcept C196843134 @default.
• W2950578201 hasConcept C2778177303 @default.
• W2950578201 hasConcept C2780358455 @default.
• W2950578201 hasConcept C31573885 @default.
• W2950578201 hasConcept C54355233 @default.
• W2950578201 hasConcept C552990157 @default.
• W2950578201 hasConcept C86803240 @default.
• W2950578201 hasConcept C87073359 @default.
• W2950578201 hasConcept C95444343 @default.

• next