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- W2950582562 abstract "Berberine (BBR, 1) is a novel cholesterol-lowering agent that up-regulates low-density-lipoprotein receptor (LDLR) expression through a mechanism different from that of statins. Because of the unique mode of action and good safety record, BBR provoked our interest to do structure modification at different domains for its cholesterol-lowering activity. Nineteen BBR analogues with substituents on the benzene ring D were synthesized in the present study. The analysis of structure-activity relationship (SAR) indicated that the two methoxyl groups in an ortho-distribution on this benzene ring afforded a good activity. Among the 19 analogues, compound 8j bearing a methoxyl at both 10- and 11-position showed an increased LDLR up-regulatory activity in respect to BBR, and therefore has been selected as a promising cholesterol-lowering drug candidate for further evaluation." @default.
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- W2950582562 date "2009-01-13" @default.
- W2950582562 modified "2023-10-18" @default.
- W2950582562 title "ChemInform Abstract: Synthesis and Structure-Activity Relationships of Berberine Analogues as a Novel Class of Low-Density-Lipoprotein Receptor Up-Regulators." @default.
- W2950582562 cites W2051641751 @default.
- W2950582562 doi "https://doi.org/10.1002/chin.200902202" @default.
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