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• W2950585022 startingPage "128" @default.
• W2950585022 abstract "Abstract Intervertebral disc degeneration and associated back pain are relatively common but sparsely understood conditions, affecting over 70% of the population during some point of life. Disc degeneration is often associated with a loss of nucleus pulposus (NP) cells. Genetic mouse models offer convenient avenues to understand the cellular and molecular regulation of the disc during its formation, growth, maintenance, and aging. However, due to the lack of inducible driver lines to precisely target NP cells in the postnatal mouse disc, progress in this area of research has been moderate. NP cells are known to express cytokeratin 19 (Krt19), and tamoxifen (Tam)‐inducible Krt19 CreERT allele is available. The current study describes the characterization of Krt19 CreERT allele to specifically and efficiently target NP cells in neonatal, skeletally mature, middle‐aged, and aged mice using two independent fluorescent reporter lines. The efficiency of recombination at all ages was validated by immunostaining for KRT19. Results show that following Tam induction, Krt19 CreERT specifically drives recombination of NP cells in the spine of neonatal and aged mice, while no recombination was detected in the surrounding tissues. Knee joints from skeletally mature Tam‐treated Krt19 CreERT/+ ; R26 tdTOM mouse show the absence of recombination in all tissues and cells of the knee joint. Thus, this study provides evidence for the use of Krt19 CreERT allele for genetic characterization of NP cells at different stages of the mouse life." @default.
• W2950585022 created "2019-06-27" @default.
• W2950585022 creator A5013946340 @default.
• W2950585022 creator A5034523499 @default.
• W2950585022 creator A5066223657 @default.
• W2950585022 date "2019-06-11" @default.
• W2950585022 modified "2023-10-10" @default.
• W2950585022 title "Characterization of <i>Krt19</i> ^{<i>CreERT</i>} allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc" @default.
• W2950585022 cites W1101293327 @default.
• W2950585022 cites W1817479092 @default.
• W2950585022 cites W1948541591 @default.
• W2950585022 cites W1964530520 @default.
• W2950585022 cites W1969154370 @default.
• W2950585022 cites W1971585190 @default.
• W2950585022 cites W1975634611 @default.
• W2950585022 cites W1976222351 @default.
• W2950585022 cites W1976430207 @default.
• W2950585022 cites W1978369267 @default.
• W2950585022 cites W1978877749 @default.
• W2950585022 cites W1993851741 @default.
• W2950585022 cites W2003621498 @default.
• W2950585022 cites W2007413067 @default.
• W2950585022 cites W2009373481 @default.
• W2950585022 cites W2012945506 @default.
• W2950585022 cites W2019744993 @default.
• W2950585022 cites W2023370307 @default.
• W2950585022 cites W2026075246 @default.
• W2950585022 cites W2036151524 @default.
• W2950585022 cites W2046158787 @default.
• W2950585022 cites W2051252239 @default.
• W2950585022 cites W2051697340 @default.
• W2950585022 cites W2051835714 @default.
• W2950585022 cites W2055942106 @default.
• W2950585022 cites W2068496177 @default.
• W2950585022 cites W2086211715 @default.
• W2950585022 cites W2086630156 @default.
• W2950585022 cites W2088645483 @default.
• W2950585022 cites W2093939680 @default.
• W2950585022 cites W2099748839 @default.
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• W2950585022 cites W2104135721 @default.
• W2950585022 cites W2113227611 @default.
• W2950585022 cites W2120690411 @default.
• W2950585022 cites W2124694620 @default.
• W2950585022 cites W2128431867 @default.
• W2950585022 cites W2137527329 @default.
• W2950585022 cites W2140432608 @default.
• W2950585022 cites W2142472354 @default.
• W2950585022 cites W2143018793 @default.
• W2950585022 cites W2148443956 @default.
• W2950585022 cites W2156119136 @default.
• W2950585022 cites W2158973504 @default.
• W2950585022 cites W2161282017 @default.
• W2950585022 cites W2165849327 @default.
• W2950585022 cites W2172129769 @default.
• W2950585022 cites W2194819592 @default.
• W2950585022 cites W2338817155 @default.
• W2950585022 cites W2382359258 @default.
• W2950585022 cites W2564427213 @default.
• W2950585022 cites W2613395463 @default.
• W2950585022 cites W2790410554 @default.
• W2950585022 cites W2794321165 @default.
• W2950585022 cites W2804067256 @default.
• W2950585022 cites W2808074975 @default.
• W2950585022 cites W2810312427 @default.
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• W2950585022 doi "https://doi.org/10.1002/jcp.28952" @default.
• W2950585022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6778700" @default.
• W2950585022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31187500" @default.
• W2950585022 hasPublicationYear "2019" @default.
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