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- W2950585518 abstract "Abstract The synthesis and preliminary biological evaluation of decarboxylated S-adenosylmethionine analogs 1 and 2 is described. In an L1210 cultured cell assay, these compounds, designed as conformationally restricted active site probes for spermidine and spermine synthase, exhibit LD 50 values of 0.1 and 1.0 mM, respectively. In addition, these compounds have significant effects on levels of cellular polyamines and S-adenosylmethionine." @default.
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- W2950585518 date "2010-08-21" @default.
- W2950585518 modified "2023-09-26" @default.
- W2950585518 title "ChemInform Abstract: Restricted Rotation Analogs of Decarboxylated S-Adenosylmethionine as Inhibitors of Polyamine Biosynthesis." @default.
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- W2950585518 doi "https://doi.org/10.1002/chin.199306301" @default.
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