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- W2950590924 abstract "Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3's role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the β3-dependent adhesome. We show that depletion of β3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2-driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when β3-integrin levels are reduced." @default.
- W2950590924 created "2019-06-27" @default.
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- W2950590924 date "2018-05-24" @default.
- W2950590924 modified "2023-10-15" @default.
- W2950590924 title "The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration" @default.
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- W2950590924 doi "https://doi.org/10.15252/embr.201744578" @default.
- W2950590924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6030693" @default.
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