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- W2950595312 abstract "Poxvirus adaptation can involve combinations of recombination-driven gene copy number variation and beneficial single nucleotide variants (SNVs) at the same loci. How these distinct mechanisms of genetic diversification might simultaneously facilitate adaptation to host immune defenses is unknown. We performed experimental evolution with vaccinia virus populations harboring a SNV in a gene actively undergoing copy number amplification. Using long sequencing reads from the Oxford Nanopore Technologies platform, we phased SNVs within large gene copy arrays for the first time. Our analysis uncovered a mechanism of adaptive SNV homogenization reminiscent of gene conversion, which is actively driven by selection. This study reveals a new mechanism for the fluid gain of beneficial mutations in genetic regions undergoing active recombination in viruses and illustrates the value of long read sequencing technologies for investigating complex genome dynamics in diverse biological systems." @default.
- W2950595312 created "2019-06-27" @default.
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- W2950595312 date "2018-08-29" @default.
- W2950595312 modified "2023-10-18" @default.
- W2950595312 title "Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays" @default.
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- W2950595312 doi "https://doi.org/10.7554/elife.35453" @default.
- W2950595312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6115191" @default.
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