Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950596548> ?p ?o ?g. }
- W2950596548 abstract "Abstract Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery without identified functional consequences. Here we report that genetic deletion of PS markedly decreases the presynaptic levels of the Ca 2+ sensor synaptotagmin-7 (Syt7) leading to impaired synaptic facilitation and replenishment of synaptic vesicles. The regulation of Syt7 expression by PS occurs post-transcriptionally and depends on γ-secretase proteolytic activity. It requires the substrate APP as revealed by the combined genetic invalidation of APP and PS1, and in particular the APP-Cterminal fragments which interact with Syt7 and accumulate in synaptic terminals under pharmacological or genetic inhibition of γ-secretase. Thus, we uncover a role of PS in presynaptic mechanisms, through APP cleavage and regulation of Syt7, that highlights aberrant synaptic vesicle processing as a possible new pathway in AD." @default.
- W2950596548 created "2019-06-27" @default.
- W2950596548 creator A5002908788 @default.
- W2950596548 creator A5006309009 @default.
- W2950596548 creator A5026052077 @default.
- W2950596548 creator A5077408587 @default.
- W2950596548 creator A5077824291 @default.
- W2950596548 creator A5079603500 @default.
- W2950596548 date "2018-11-14" @default.
- W2950596548 modified "2023-10-14" @default.
- W2950596548 title "Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity" @default.
- W2950596548 cites W1593060735 @default.
- W2950596548 cites W1655404681 @default.
- W2950596548 cites W1869318026 @default.
- W2950596548 cites W1875687345 @default.
- W2950596548 cites W1984678540 @default.
- W2950596548 cites W1988986946 @default.
- W2950596548 cites W1989334850 @default.
- W2950596548 cites W1989396363 @default.
- W2950596548 cites W1990752558 @default.
- W2950596548 cites W1999204642 @default.
- W2950596548 cites W2010905290 @default.
- W2950596548 cites W2019455594 @default.
- W2950596548 cites W2027140832 @default.
- W2950596548 cites W2030641075 @default.
- W2950596548 cites W2032523363 @default.
- W2950596548 cites W2035949357 @default.
- W2950596548 cites W2038602552 @default.
- W2950596548 cites W2046209489 @default.
- W2950596548 cites W2050989831 @default.
- W2950596548 cites W2059591772 @default.
- W2950596548 cites W2059854005 @default.
- W2950596548 cites W2066972166 @default.
- W2950596548 cites W2073660598 @default.
- W2950596548 cites W2074814566 @default.
- W2950596548 cites W2081173735 @default.
- W2950596548 cites W2082022687 @default.
- W2950596548 cites W2088944569 @default.
- W2950596548 cites W2095144685 @default.
- W2950596548 cites W2103787070 @default.
- W2950596548 cites W2105631420 @default.
- W2950596548 cites W2112759299 @default.
- W2950596548 cites W2113166966 @default.
- W2950596548 cites W2113309691 @default.
- W2950596548 cites W2124716843 @default.
- W2950596548 cites W2124733101 @default.
- W2950596548 cites W2126864626 @default.
- W2950596548 cites W2128863253 @default.
- W2950596548 cites W2133378263 @default.
- W2950596548 cites W2135024966 @default.
- W2950596548 cites W2154755614 @default.
- W2950596548 cites W2156326104 @default.
- W2950596548 cites W2235731016 @default.
- W2950596548 cites W2318541701 @default.
- W2950596548 cites W2323101848 @default.
- W2950596548 cites W2331918673 @default.
- W2950596548 cites W2559772302 @default.
- W2950596548 cites W2572503237 @default.
- W2950596548 cites W2593220908 @default.
- W2950596548 cites W2599851926 @default.
- W2950596548 cites W2600134249 @default.
- W2950596548 doi "https://doi.org/10.1038/s41467-018-06813-x" @default.
- W2950596548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6235831" @default.
- W2950596548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30429473" @default.
- W2950596548 hasPublicationYear "2018" @default.
- W2950596548 type Work @default.
- W2950596548 sameAs 2950596548 @default.
- W2950596548 citedByCount "43" @default.
- W2950596548 countsByYear W29505965482019 @default.
- W2950596548 countsByYear W29505965482020 @default.
- W2950596548 countsByYear W29505965482021 @default.
- W2950596548 countsByYear W29505965482022 @default.
- W2950596548 countsByYear W29505965482023 @default.
- W2950596548 crossrefType "journal-article" @default.
- W2950596548 hasAuthorship W2950596548A5002908788 @default.
- W2950596548 hasAuthorship W2950596548A5006309009 @default.
- W2950596548 hasAuthorship W2950596548A5026052077 @default.
- W2950596548 hasAuthorship W2950596548A5077408587 @default.
- W2950596548 hasAuthorship W2950596548A5077824291 @default.
- W2950596548 hasAuthorship W2950596548A5079603500 @default.
- W2950596548 hasBestOaLocation W29505965481 @default.
- W2950596548 hasConcept C126322002 @default.
- W2950596548 hasConcept C130316041 @default.
- W2950596548 hasConcept C148785051 @default.
- W2950596548 hasConcept C169760540 @default.
- W2950596548 hasConcept C170493617 @default.
- W2950596548 hasConcept C175344181 @default.
- W2950596548 hasConcept C181199279 @default.
- W2950596548 hasConcept C185592680 @default.
- W2950596548 hasConcept C200170125 @default.
- W2950596548 hasConcept C2776219046 @default.
- W2950596548 hasConcept C2776714187 @default.
- W2950596548 hasConcept C2779134260 @default.
- W2950596548 hasConcept C2909695770 @default.
- W2950596548 hasConcept C31705614 @default.
- W2950596548 hasConcept C36103677 @default.
- W2950596548 hasConcept C41007966 @default.
- W2950596548 hasConcept C41625074 @default.
- W2950596548 hasConcept C502032728 @default.
- W2950596548 hasConcept C529278444 @default.