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- W2950622756 endingPage "e13747" @default.
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- W2950622756 abstract "GABAergic inhibition plays a critical role in the regulation of neuronal activity. In the neocortex, inhibitory interneurons that target the dendrites of pyramidal cells influence both electrical and biochemical postsynaptic signaling. Voltage-gated ion channels strongly shape dendritic excitability and the integration of excitatory inputs, but their contribution to GABAergic signaling is less well understood. By combining 2-photon calcium imaging and focal GABA uncaging, we show that voltage-gated potassium channels normally suppress the GABAergic inhibition of calcium signals evoked by back-propagating action potentials in dendritic spines and shafts of cortical pyramidal neurons. Moreover, the voltage-dependent inactivation of these channels leads to enhancement of dendritic calcium inhibition following somatic spiking. Computational modeling reveals that the enhancement of calcium inhibition involves an increase in action potential depolarization coupled with the nonlinear relationship between membrane voltage and calcium channel activation. Overall, our findings highlight the interaction between intrinsic and synaptic properties and reveal a novel mechanism for the activity-dependent regulation of GABAergic inhibition." @default.
- W2950622756 created "2019-06-27" @default.
- W2950622756 creator A5031151569 @default.
- W2950622756 creator A5044553615 @default.
- W2950622756 date "2018-06-01" @default.
- W2950622756 modified "2023-10-15" @default.
- W2950622756 title "Potassium channels contribute to activity-dependent regulation of dendritic inhibition" @default.
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- W2950622756 doi "https://doi.org/10.14814/phy2.13747" @default.
- W2950622756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6016672" @default.
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