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- W2950638081 abstract "Abstract mRNA localization serves key functions in localized protein production making it critical that the translation machinery itself is present at these locations. Here we show that translation factor mRNAs are localized to distinct granules within yeast cells. In contrast to many mRNP granules, such as P-bodies and stress granules, which contain translationally repressed mRNAs, these granules harbor translated mRNAs under active growth conditions. The granules require Pablp for their integrity and are inherited by developing daughter cells in a She2p/ She3p dependent manner. These results point to a model where roughly half the mRNA for certain translation factors are specifically directed in granules toward the tip of the developing daughter cell where protein synthesis is most heavily required, which has particular implications for filamentous forms of growth. Such a feedforward mechanism would ensure adequate provision of the translation machinery where it is to be needed most over the coming growth cycle. Summary This study shows that mRNAs encoding a range of translation factors are localized to granules that get transported into the yeast daughter cell using the She2p/She3p machinery. This likely supports an intensification of protein synthetic activity to facilitate apical polarized growth." @default.
- W2950638081 created "2019-06-27" @default.
- W2950638081 creator A5008975261 @default.
- W2950638081 creator A5025232181 @default.
- W2950638081 creator A5029562317 @default.
- W2950638081 creator A5032920121 @default.
- W2950638081 creator A5034703497 @default.
- W2950638081 creator A5042407160 @default.
- W2950638081 creator A5056894026 @default.
- W2950638081 creator A5057668285 @default.
- W2950638081 creator A5063136560 @default.
- W2950638081 creator A5071550154 @default.
- W2950638081 creator A5075887697 @default.
- W2950638081 creator A5076860346 @default.
- W2950638081 date "2018-10-19" @default.
- W2950638081 modified "2023-10-09" @default.
- W2950638081 title "Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth" @default.
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