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• W2950649552 abstract "Buprenorphine analogs have been synthesized. In the studies of analgesic and addictive effects in mice and [(35)S]GTPgammaS binding assay in human brain tissue, an analog of buprenorphine where the tert-butyl is replaced by a cyclobutyl moiety (16) has been identified as a selective kappa-partial agonist which gives antinociceptive effects, but has low abuse potential. The results may lead to lower degrees of dysphoria than full kappa-agonists." @default.
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• W2950649552 date "2006-07-01" @default.
• W2950649552 modified "2023-10-07" @default.
• W2950649552 title "A highly selective κ-opioid receptor agonist with low addictive potential and dependence liability" @default.
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• W2950649552 doi "https://doi.org/10.1016/j.bmcl.2006.02.017" @default.
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