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- W2950656592 endingPage "e1006382" @default.
- W2950656592 startingPage "e1006382" @default.
- W2950656592 abstract "Early afterdepolarizations (EADs) are spontaneous depolarizations during the repolarization phase of an action potential in cardiac myocytes. It is widely known that EADs are promoted by increasing inward currents and/or decreasing outward currents, a condition called reduced repolarization reserve. Recent studies based on bifurcation theories show that EADs are caused by a dual Hopf-homoclinic bifurcation, bringing in further mechanistic insights into the genesis and dynamics of EADs. In this study, we investigated the EAD properties, such as the EAD amplitude, the inter-EAD interval, and the latency of the first EAD, and their major determinants. We first made predictions based on the bifurcation theory and then validated them in physiologically more detailed action potential models. These properties were investigated by varying one parameter at a time or using parameter sets randomly drawn from assigned intervals. The theoretical and simulation results were compared with experimental data from the literature. Our major findings are that the EAD amplitude and takeoff potential exhibit a negative linear correlation; the inter-EAD interval is insensitive to the maximum ionic current conductance but mainly determined by the kinetics of ICa,L and the dual Hopf-homoclinic bifurcation; and both inter-EAD interval and latency vary largely from model to model. Most of the model results generally agree with experimental observations in isolated ventricular myocytes. However, a major discrepancy between modeling results and experimental observations is that the inter-EAD intervals observed in experiments are mainly between 200 and 500 ms, irrespective of species, while those of the mathematical models exhibit a much wider range with some models exhibiting inter-EAD intervals less than 100 ms. Our simulations show that the cause of this discrepancy is likely due to the difference in ICa,L recovery properties in different mathematical models, which needs to be addressed in future action potential model development." @default.
- W2950656592 created "2019-06-27" @default.
- W2950656592 creator A5007444000 @default.
- W2950656592 creator A5035064117 @default.
- W2950656592 creator A5051699207 @default.
- W2950656592 date "2018-11-26" @default.
- W2950656592 modified "2023-10-18" @default.
- W2950656592 title "Determinants of early afterdepolarization properties in ventricular myocyte models" @default.
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- W2950656592 cites W1981680918 @default.
- W2950656592 cites W1984410328 @default.
- W2950656592 cites W1985032406 @default.
- W2950656592 cites W1990863350 @default.
- W2950656592 cites W1991992462 @default.
- W2950656592 cites W1993613402 @default.
- W2950656592 cites W1998431529 @default.
- W2950656592 cites W2003654791 @default.
- W2950656592 cites W2013536970 @default.
- W2950656592 cites W2016451755 @default.
- W2950656592 cites W2028146834 @default.
- W2950656592 cites W2028721157 @default.
- W2950656592 cites W2030816979 @default.
- W2950656592 cites W2032010993 @default.
- W2950656592 cites W2038131479 @default.
- W2950656592 cites W2038657224 @default.
- W2950656592 cites W2039356074 @default.
- W2950656592 cites W2049462987 @default.
- W2950656592 cites W2050584392 @default.
- W2950656592 cites W2053381822 @default.
- W2950656592 cites W2054192482 @default.
- W2950656592 cites W2054839336 @default.
- W2950656592 cites W2055752231 @default.
- W2950656592 cites W2058178946 @default.
- W2950656592 cites W2060489949 @default.
- W2950656592 cites W2061451182 @default.
- W2950656592 cites W2066742955 @default.
- W2950656592 cites W2067694391 @default.
- W2950656592 cites W2072797200 @default.
- W2950656592 cites W2077113957 @default.
- W2950656592 cites W2077424966 @default.
- W2950656592 cites W2080804559 @default.
- W2950656592 cites W2082750072 @default.
- W2950656592 cites W2083703896 @default.
- W2950656592 cites W2086084827 @default.
- W2950656592 cites W2094881857 @default.
- W2950656592 cites W2097750265 @default.
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- W2950656592 cites W2098367638 @default.
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- W2950656592 cites W2103036074 @default.
- W2950656592 cites W2103223481 @default.
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- W2950656592 cites W2138039832 @default.
- W2950656592 cites W2142432219 @default.
- W2950656592 cites W2143764133 @default.
- W2950656592 cites W2152074480 @default.
- W2950656592 cites W2154806697 @default.
- W2950656592 cites W2162228881 @default.
- W2950656592 cites W2164379882 @default.
- W2950656592 cites W2168841938 @default.
- W2950656592 cites W2171833061 @default.
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- W2950656592 cites W2528419909 @default.
- W2950656592 cites W2550401332 @default.
- W2950656592 cites W2760072766 @default.
- W2950656592 cites W2791055780 @default.
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- W2950656592 doi "https://doi.org/10.1371/journal.pcbi.1006382" @default.
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- W2950656592 hasPublicationYear "2018" @default.
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