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- W2950658269 endingPage "121" @default.
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- W2950658269 abstract "Filamentous fungi produce a vast number of bioactive secondary metabolites (SMs), some of which have found applications in the pharmaceutical industry including as antibiotics and immunosuppressants. As more and more species are whole genome sequenced the number of predicted clusters of genes for SM biosynthesis is ever increasing - holding a promise of novel useful bioactive SMs. To be able to fully utilize the potential of novel SMs, it is necessary to link the SM and the genes responsible for producing it. This can be challenging, but many strategies and tools have been developed for this purpose. Here we provide an overview of the methods used to establish the link between SM and biosynthetic gene cluster (BGC) and vice versa, along with the challenges and advantages of each of the methods. Part I of the review, associating BCG with SM, is divided into gene manipulations native strain and heterologous expression strategies, depending on the fungal species. Part II, associating SM with BGC, is divided into three main approaches: (1) homology search (2) retro-biosynthesis and (3) comparative genomics." @default.
- W2950658269 created "2019-06-27" @default.
- W2950658269 creator A5003008647 @default.
- W2950658269 creator A5008278783 @default.
- W2950658269 creator A5054589286 @default.
- W2950658269 creator A5054962508 @default.
- W2950658269 date "2019-09-01" @default.
- W2950658269 modified "2023-10-03" @default.
- W2950658269 title "Strategies to establish the link between biosynthetic gene clusters and secondary metabolites" @default.
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