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- W2950665616 abstract "(24R)-27-Nor-5β-cholestane-3α,7α,12α,24,26-pentol (5β-ranol) has been synthesised by theWittig olefinic coupling of a steroidal module and a side-chain modulefollowed by reduction and deprotection. The steroidal module is derivedfrom cholic acid by a one-carbon degradation of the side chain toproduce norcholic acid followed by the loss of a second carbon in aniododecarboxylation and then synthesis of the triphenylphosphoniumiodide. The side-chain module is derived from(S)-(-)-butane-1,2,4-triol by benzylideneprotection of the 2,4-diol followed by Swern oxidation to the aldehyde.This general synthetic scheme could be used to produce a range of bilesterols with the (24R)-hydroxy moiety which may havesignificant hepatoprotective activity against liver damage induced byfree radicals or reactive metabolites." @default.
- W2950665616 created "2019-06-27" @default.
- W2950665616 creator A5051299870 @default.
- W2950665616 creator A5063693485 @default.
- W2950665616 date "2010-08-03" @default.
- W2950665616 modified "2023-09-26" @default.
- W2950665616 title "ChemInform Abstract: A New Chiral Synthesis of Bullfrog Bile Sterol 5β-Ranol." @default.
- W2950665616 cites W2021447102 @default.
- W2950665616 doi "https://doi.org/10.1002/chin.199741242" @default.
- W2950665616 hasPublicationYear "2010" @default.
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