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• W2950668082 abstract "Abstract The mechanism by which GSAP (γ-secretase activating protein) regulates γ-secretase activity has not yet been elucidated. Here, we show that knockout of GSAP in cultured cells directly reduces γ-secretase activity for Aβ production, but not for Notch1 cleavage, suggesting that GSAP may induce a conformational change contributing to the specificity of γ-secretase. Furthermore, using an active site directed photoprobe with double cross-linking moieties, we demonstrate that GSAP modifies the orientation and/or distance of PS1-NTF and PS1-CTF, a region containing the active site of γ-secretase. This work offers insight into how GSAP regulates γ-secretase specificity." @default.
• W2950668082 created "2019-06-27" @default.
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• W2950668082 date "2018-11-07" @default.
• W2950668082 modified "2023-10-16" @default.
• W2950668082 title "GSAP modulates γ-secretase specificity by inducing conformational change in PS1" @default.
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• W2950668082 doi "https://doi.org/10.1101/461061" @default.
• W2950668082 hasPublicationYear "2018" @default.
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