FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950673723> ?p ?o ?g. }

• W2950673723 abstract "Abstract Hypoxic exposure during development can have a profound influence on offspring physiology, including cardiac dysfunction, yet many reptile embryos naturally experience periods of hypoxia in buried nests. American alligators experimentally exposed to developmental hypoxia demonstrate morphological and functional changes to the heart that persist into later life stages; however, the molecular bases of these changes remain unknown. We tested if targeted and persistent changes in steady-state protein expression underlie this hypoxic heart phenotype, using isobaric tags for relative and absolute quantitation (iTRAQ) proteomics. Alligator eggs were reared under normoxia or 10% hypoxia, then either sampled (embryo) or returned to normoxia for 2 years (juvenile). Three salient findings emerge from the integrated analysis of the 145 differentially expressed proteins in hypoxia-reared animals: (1) significant protein-protein interaction networks were identified only in up-regulated proteins, indicating that the effects of developmental hypoxia are stimulatory and directed; (2) the up-regulated proteins substantially enriched processes related to protein turnover, cellular organization, and metabolic pathways, supporting increased resource allocation towards building and maintaining a higher functioning heart; and (3) the juvenile cardiac proteome retained many of the signature changes observed in embryonic hearts, supporting long-term reprogramming of cardiac myocytes induced by hypoxia during critical periods of development." @default.
• W2950673723 created "2019-06-27" @default.
• W2950673723 creator A5031644961 @default.
• W2950673723 creator A5055240222 @default.
• W2950673723 creator A5059248505 @default.
• W2950673723 creator A5091787062 @default.
• W2950673723 date "2019-06-13" @default.
• W2950673723 modified "2023-10-14" @default.
• W2950673723 title "Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics" @default.
• W2950673723 cites W1545536250 @default.
• W2950673723 cites W1953419063 @default.
• W2950673723 cites W1969353942 @default.
• W2950673723 cites W1973592885 @default.
• W2950673723 cites W1979036123 @default.
• W2950673723 cites W1994714922 @default.
• W2950673723 cites W1997412397 @default.
• W2950673723 cites W2010044577 @default.
• W2950673723 cites W2012057388 @default.
• W2950673723 cites W2017685939 @default.
• W2950673723 cites W2020691788 @default.
• W2950673723 cites W2021731777 @default.
• W2950673723 cites W2044080600 @default.
• W2950673723 cites W2075428562 @default.
• W2950673723 cites W2081171362 @default.
• W2950673723 cites W2092777541 @default.
• W2950673723 cites W2100010469 @default.
• W2950673723 cites W2103185094 @default.
• W2950673723 cites W2107865775 @default.
• W2950673723 cites W2130981336 @default.
• W2950673723 cites W2140498210 @default.
• W2950673723 cites W2140893048 @default.
• W2950673723 cites W2149876082 @default.
• W2950673723 cites W2319676188 @default.
• W2950673723 cites W2333857008 @default.
• W2950673723 cites W2336404712 @default.
• W2950673723 cites W2338004619 @default.
• W2950673723 cites W2463195069 @default.
• W2950673723 cites W2467553857 @default.
• W2950673723 cites W2513679276 @default.
• W2950673723 cites W2528325896 @default.
• W2950673723 cites W2550862771 @default.
• W2950673723 cites W2598497091 @default.
• W2950673723 cites W2598885031 @default.
• W2950673723 cites W2606842029 @default.
• W2950673723 cites W2612410801 @default.
• W2950673723 cites W2694192138 @default.
• W2950673723 cites W2782045251 @default.
• W2950673723 cites W2801127590 @default.
• W2950673723 cites W2885173917 @default.
• W2950673723 cites W2890596124 @default.
• W2950673723 cites W4244580242 @default.
• W2950673723 doi "https://doi.org/10.1038/s41598-019-45023-3" @default.
• W2950673723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6565670" @default.
• W2950673723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31197188" @default.
• W2950673723 hasPublicationYear "2019" @default.
• W2950673723 type Work @default.
• W2950673723 sameAs 2950673723 @default.
• W2950673723 citedByCount "16" @default.
• W2950673723 countsByYear W29506737232020 @default.
• W2950673723 countsByYear W29506737232021 @default.
• W2950673723 countsByYear W29506737232022 @default.
• W2950673723 countsByYear W29506737232023 @default.
• W2950673723 crossrefType "journal-article" @default.
• W2950673723 hasAuthorship W2950673723A5031644961 @default.
• W2950673723 hasAuthorship W2950673723A5055240222 @default.
• W2950673723 hasAuthorship W2950673723A5059248505 @default.
• W2950673723 hasAuthorship W2950673723A5091787062 @default.
• W2950673723 hasBestOaLocation W29506737231 @default.
• W2950673723 hasConcept C104317684 @default.
• W2950673723 hasConcept C104397665 @default.
• W2950673723 hasConcept C112672928 @default.
• W2950673723 hasConcept C115961737 @default.
• W2950673723 hasConcept C126322002 @default.
• W2950673723 hasConcept C127716648 @default.
• W2950673723 hasConcept C145103041 @default.
• W2950673723 hasConcept C151730666 @default.
• W2950673723 hasConcept C178790620 @default.
• W2950673723 hasConcept C185592680 @default.
• W2950673723 hasConcept C196843134 @default.
• W2950673723 hasConcept C2779234561 @default.
• W2950673723 hasConcept C2779832703 @default.
• W2950673723 hasConcept C2909117068 @default.
• W2950673723 hasConcept C46111723 @default.
• W2950673723 hasConcept C540031477 @default.
• W2950673723 hasConcept C54355233 @default.
• W2950673723 hasConcept C60644358 @default.
• W2950673723 hasConcept C62425271 @default.
• W2950673723 hasConcept C71924100 @default.
• W2950673723 hasConcept C77255625 @default.
• W2950673723 hasConcept C7836513 @default.
• W2950673723 hasConcept C86803240 @default.
• W2950673723 hasConcept C95444343 @default.
• W2950673723 hasConceptScore W2950673723C104317684 @default.
• W2950673723 hasConceptScore W2950673723C104397665 @default.
• W2950673723 hasConceptScore W2950673723C112672928 @default.
• W2950673723 hasConceptScore W2950673723C115961737 @default.
• W2950673723 hasConceptScore W2950673723C126322002 @default.
• W2950673723 hasConceptScore W2950673723C127716648 @default.
• W2950673723 hasConceptScore W2950673723C145103041 @default.
• W2950673723 hasConceptScore W2950673723C151730666 @default.

• next