Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950676576> ?p ?o ?g. }
- W2950676576 abstract "Abstract We and others have shown that transition and maintenance of biological states is controlled by master regulator proteins, which can be inferred by interrogating tissue-specific regulatory models (interactomes) with transcriptional signatures, using the VIPER algorithm. Yet, some tissues may lack molecular profiles necessary for interactome inference (orphan tissues), or, as for single cells isolated from heterogeneous samples, their tissue context may be undetermined. To address this problem, we introduce metaVIPER, an algorithm designed to assess protein activity in tissue-independent fashion by integrative analysis of multiple, non-tissue-matched interactomes. This assumes that transcriptional targets of each protein will be recapitulated by one or more available interactomes. We confirm the algorithm’s value in assessing protein dysregulation induced by somatic mutations, as well as in assessing protein activity in orphan tissues and, most critically, in single cells, thus allowing transformation of noisy and potentially biased RNA-Seq signatures into reproducible protein-activity signatures." @default.
- W2950676576 created "2019-06-27" @default.
- W2950676576 creator A5007886308 @default.
- W2950676576 creator A5013037807 @default.
- W2950676576 creator A5017756904 @default.
- W2950676576 creator A5026261277 @default.
- W2950676576 creator A5046245448 @default.
- W2950676576 creator A5046673359 @default.
- W2950676576 creator A5050681627 @default.
- W2950676576 creator A5056970732 @default.
- W2950676576 creator A5060408739 @default.
- W2950676576 creator A5079815463 @default.
- W2950676576 date "2018-04-16" @default.
- W2950676576 modified "2023-10-14" @default.
- W2950676576 title "Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm" @default.
- W2950676576 cites W1649547160 @default.
- W2950676576 cites W1763220019 @default.
- W2950676576 cites W1913086588 @default.
- W2950676576 cites W1963522244 @default.
- W2950676576 cites W1964081206 @default.
- W2950676576 cites W1967261754 @default.
- W2950676576 cites W1967327758 @default.
- W2950676576 cites W1982635732 @default.
- W2950676576 cites W1984748997 @default.
- W2950676576 cites W1999574084 @default.
- W2950676576 cites W2002726823 @default.
- W2950676576 cites W2018653121 @default.
- W2950676576 cites W2032243801 @default.
- W2950676576 cites W2034030391 @default.
- W2950676576 cites W2061574308 @default.
- W2950676576 cites W2071268727 @default.
- W2950676576 cites W2076583198 @default.
- W2950676576 cites W2076682664 @default.
- W2950676576 cites W2077128508 @default.
- W2950676576 cites W2078149659 @default.
- W2950676576 cites W2087634573 @default.
- W2950676576 cites W2092010840 @default.
- W2950676576 cites W2098023402 @default.
- W2950676576 cites W2103894337 @default.
- W2950676576 cites W2105031411 @default.
- W2950676576 cites W2105280376 @default.
- W2950676576 cites W2106608030 @default.
- W2950676576 cites W2107648723 @default.
- W2950676576 cites W2110265246 @default.
- W2950676576 cites W2111882541 @default.
- W2950676576 cites W2113942802 @default.
- W2950676576 cites W2116634113 @default.
- W2950676576 cites W2117692326 @default.
- W2950676576 cites W2125631472 @default.
- W2950676576 cites W2129957034 @default.
- W2950676576 cites W2130410032 @default.
- W2950676576 cites W2144710927 @default.
- W2950676576 cites W2152239989 @default.
- W2950676576 cites W2157505508 @default.
- W2950676576 cites W2158357903 @default.
- W2950676576 cites W2159600984 @default.
- W2950676576 cites W2161289668 @default.
- W2950676576 cites W2161409973 @default.
- W2950676576 cites W2162143298 @default.
- W2950676576 cites W2163584800 @default.
- W2950676576 cites W2166773843 @default.
- W2950676576 cites W2168204924 @default.
- W2950676576 cites W2169385554 @default.
- W2950676576 cites W2170505338 @default.
- W2950676576 cites W2181003249 @default.
- W2950676576 cites W2190545194 @default.
- W2950676576 cites W2200183975 @default.
- W2950676576 cites W2263206910 @default.
- W2950676576 cites W2325651197 @default.
- W2950676576 cites W2332292689 @default.
- W2950676576 cites W2339613031 @default.
- W2950676576 cites W2471249441 @default.
- W2950676576 cites W2472255748 @default.
- W2950676576 cites W2566656214 @default.
- W2950676576 cites W2605406321 @default.
- W2950676576 cites W2612502013 @default.
- W2950676576 cites W2737785069 @default.
- W2950676576 cites W3099289621 @default.
- W2950676576 doi "https://doi.org/10.1038/s41467-018-03843-3" @default.
- W2950676576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5902599" @default.
- W2950676576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29662057" @default.
- W2950676576 hasPublicationYear "2018" @default.
- W2950676576 type Work @default.
- W2950676576 sameAs 2950676576 @default.
- W2950676576 citedByCount "85" @default.
- W2950676576 countsByYear W29506765762017 @default.
- W2950676576 countsByYear W29506765762018 @default.
- W2950676576 countsByYear W29506765762019 @default.
- W2950676576 countsByYear W29506765762020 @default.
- W2950676576 countsByYear W29506765762021 @default.
- W2950676576 countsByYear W29506765762022 @default.
- W2950676576 countsByYear W29506765762023 @default.
- W2950676576 crossrefType "journal-article" @default.
- W2950676576 hasAuthorship W2950676576A5007886308 @default.
- W2950676576 hasAuthorship W2950676576A5013037807 @default.
- W2950676576 hasAuthorship W2950676576A5017756904 @default.
- W2950676576 hasAuthorship W2950676576A5026261277 @default.
- W2950676576 hasAuthorship W2950676576A5046245448 @default.
- W2950676576 hasAuthorship W2950676576A5046673359 @default.
- W2950676576 hasAuthorship W2950676576A5050681627 @default.