Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950695773> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W2950695773 abstract "The mitomycins (Figure 1) are a unique family of natural products with a rich history. Hata and coworkers at Kwoya Hakko Kogyo Company in Japan first isolated mitomycins A and B from Streptomyces caespitosus found in soil samples in 1956.[1-3] Although the mitomycins were isolated by researchers at Kwoya Hakko Kogyo, the absolute structure of the mitomycins was determined by Webb and Coworkers at American Cyanamid Company.[4,5] X-ray crystal structures of the mitomycins by Tulinsky also proved critical in determination of the structures of the mitomycins.[6,7] Since that time a number of other members of this family of natural products have been isolated, including FR-900482 and FR-66979 from Streptomyces sandaensis in 1988 (Figure 1).[8, 9]Figure 1Members of the mitomycin family of natural products.The biological activity attributed to this family of natural products is a manifestation of their ability to form both inter- and intra-strand DNA cross-links in the minor groove with a specificity favoring 5′-CG-3′ steps.[10,11] At the time of this discovery, no previous examples of natural products acting as DNA cross-linking agents were known. It was after this initial finding that several other natural products were found to also form cross-links with DNA.[12-14] Recent studies have shown that in addition to the formation of DNA cross-links, this family of compounds is also capable of forming cross-links with minor groove-binding nuclear proteins, such as high mobility group I/Y (HMG I/Y now named HMG A1) proteins.[15,16] Additionally, it was shown that monoalkylation and not cross-linking was the major adduct found when an FR-900482 derivative was incubated with nucleosomes. This result could suggest alternate modes of action of this family of natural products in the context of cellular chromatin." @default.
- W2950695773 created "2019-06-27" @default.
- W2950695773 creator A5002113213 @default.
- W2950695773 creator A5008180276 @default.
- W2950695773 creator A5017883993 @default.
- W2950695773 creator A5044035323 @default.
- W2950695773 date "2013-09-19" @default.
- W2950695773 modified "2023-09-27" @default.
- W2950695773 title "ChemInform Abstract: Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches" @default.
- W2950695773 cites W1969279448 @default.
- W2950695773 doi "https://doi.org/10.1002/chin.201341231" @default.
- W2950695773 hasPublicationYear "2013" @default.
- W2950695773 type Work @default.
- W2950695773 sameAs 2950695773 @default.
- W2950695773 citedByCount "0" @default.
- W2950695773 crossrefType "journal-article" @default.
- W2950695773 hasAuthorship W2950695773A5002113213 @default.
- W2950695773 hasAuthorship W2950695773A5008180276 @default.
- W2950695773 hasAuthorship W2950695773A5017883993 @default.
- W2950695773 hasAuthorship W2950695773A5044035323 @default.
- W2950695773 hasConcept C185592680 @default.
- W2950695773 hasConcept C2779920670 @default.
- W2950695773 hasConcept C523546767 @default.
- W2950695773 hasConcept C54355233 @default.
- W2950695773 hasConcept C552990157 @default.
- W2950695773 hasConcept C55493867 @default.
- W2950695773 hasConcept C71240020 @default.
- W2950695773 hasConcept C86803240 @default.
- W2950695773 hasConceptScore W2950695773C185592680 @default.
- W2950695773 hasConceptScore W2950695773C2779920670 @default.
- W2950695773 hasConceptScore W2950695773C523546767 @default.
- W2950695773 hasConceptScore W2950695773C54355233 @default.
- W2950695773 hasConceptScore W2950695773C552990157 @default.
- W2950695773 hasConceptScore W2950695773C55493867 @default.
- W2950695773 hasConceptScore W2950695773C71240020 @default.
- W2950695773 hasConceptScore W2950695773C86803240 @default.
- W2950695773 hasLocation W29506957731 @default.
- W2950695773 hasOpenAccess W2950695773 @default.
- W2950695773 hasPrimaryLocation W29506957731 @default.
- W2950695773 hasRelatedWork W2013423948 @default.
- W2950695773 isParatext "false" @default.
- W2950695773 isRetracted "false" @default.
- W2950695773 magId "2950695773" @default.
- W2950695773 workType "article" @default.