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- W2950744291 abstract "A series of 1-[3-(acylthio)-3-aroylpropionyl]-L-proline derivatives was synthesized. A number of these compounds are potent angiotensin converting enzyme (ACE) inhibitors that lowered blood pressure in aorta-coarcted renal hypertensive rats. The most active derivatives are 1-[3(R)-(acetylthio) -3-substituted-benzoyl)-2(S)-methyl-propionyl]-L-prolines with an in vivo activity equivalent to SQ 14,225 (captopril). Structure-activity relationships are discussed. Changes in the configuration of the alpha-methyl group and the S-acetyl group affect the ACE activity. Coupling of 3-(substituted-benzoyl)-2-methylpropionic acids to L-proline via enol lactones is described." @default.
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- W2950744291 date "1983-08-23" @default.
- W2950744291 modified "2023-09-23" @default.
- W2950744291 title "ChemInform Abstract: ANTIHYPERTENSIVE AGENTS: ANGIOTENSIN CONVERTING ENZYME INHIBITORS. 1-(3-(ACYLTHIO)-3-AROYLPROPIONYL)-L-PROLINES" @default.
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- W2950744291 doi "https://doi.org/10.1002/chin.198334180" @default.
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