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- W2950744367 abstract "Abstract At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic expression of the oncogene vSrc in a simple epithelium of the early zebrafish embryo results in extrusion of transformed cells. Here we find that during extrusion components of the cytokinetic ring are recruited to adherens junctions of transformed cells, forming a misoriented pseudo-cytokinetic ring. As the ring constricts, it separates the basal from the apical part of the cell releasing both from the epithelium. This process requires cell cycle progression and occurs immediately after vSrc-transformed cell enters mitosis. To achieve extrusion, vSrc coordinates cell cycle progression, junctional integrity, cell survival and apicobasal polarity. Without vSrc, modulating these cellular processes reconstitutes vSrc-like extrusion, confirming their sufficiency for this process." @default.
- W2950744367 created "2019-06-27" @default.
- W2950744367 creator A5027643417 @default.
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- W2950744367 creator A5078393139 @default.
- W2950744367 date "2018-11-08" @default.
- W2950744367 modified "2023-10-13" @default.
- W2950744367 title "Src-transformed cells hijack mitosis to extrude from the epithelium" @default.
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- W2950744367 doi "https://doi.org/10.1038/s41467-018-07163-4" @default.
- W2950744367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224566" @default.
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