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- W2950746549 abstract "The N5-C6 double bond of NK109 (an antitumor benzo[c]phenanthridine alkaloid) is easily reduced under biological environment. To suppress the inactivation caused by reduction, we synthesized 5-, 6-, and 8-substituted NK109. 5-Substituted derivatives (4a-c) were reduced more easily than NK109. 6-Substituted ones (10a-f) inhibited biological reduction, but showed weak cytotoxic activity. 8-O-Substituted ones (13a-h), especially 8-O-hydroxyethyl NK109 (13d), suppressed biological reduction and exhibited strong cytotoxic activity." @default.
- W2950746549 created "2019-06-27" @default.
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- W2950746549 date "2001-01-23" @default.
- W2950746549 modified "2023-09-27" @default.
- W2950746549 title "ChemInform Abstract: Synthesis of Derivatives of NK109, 7-OH Benzo[c]phenanthridine Alkaloid, and Evaluation of Their Cytotoxicities and Reduction-Resistant Properties." @default.
- W2950746549 cites W2071757584 @default.
- W2950746549 doi "https://doi.org/10.1002/chin.200104217" @default.
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