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- W2950748425 abstract "N-Acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and thirteen new analogs were synthesized by the conventional organic chemical procedure using dicyclohexylcarbodiimide-N-hydroxy-5-norbornene-2,3-dicarboximide as a coupling agent. Their ability to induce delayed-type hypersensitivity to N-acetyl-3-(4-arsonophenylazo)-L-tyrosine in guinea pigs was assayed. The results indicate that the presence of an α-amino acid adjacent to the lactic acid moiety in MDP is important for the high biological activity, the valine analog having the most favorable effect. The structure-activity relationship is discussed." @default.
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- W2950748425 date "1980-12-09" @default.
- W2950748425 modified "2023-09-24" @default.
- W2950748425 title "ChemInform Abstract: SYNTHESIS OF MURAMYL DIPEPTIDE ANALOGS WITH ENHANCED ADJUVANT ACTIVITY" @default.
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- W2950748425 doi "https://doi.org/10.1002/chin.198049320" @default.
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