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• W2950759852 abstract "Objective: The objective of this study was to entrap water-insoluble drug itraconazole into polymer to form drug entrapped nanoparticles by using simple formulation strategy and characterize them for various in vitro properties. Method: Itraconazole (ITZ) encapsulated Eudragit E 100 nanoparticles (IEENs) were formulated by emulsification solvent evaporation technique. Results: Developed IEENs were evaluated for entrapment efficiency, particle size, polydispersity index, and drug release profile. It was clear that drug polymer ratio along with homogenization speed are the factors affecting droplet size of an emulsion. Evaluation was done by HPLC at 263nm. DSC, XRD studies were carried out. The in vitro antifungal study of nanoparticles suggested that they are more effective in inhibiting growth of Candida albicans. Conclusion: The results from this study suggest the potential use of IEENs to provide a possible way of improving solubility and thus oral absorption of Itraconazole. Thus the study concluded that IEENs have potential to effectively treat the fungal infection." @default.
• W2950759852 created "2019-06-27" @default.
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• W2950759852 date "2020-01-14" @default.
• W2950759852 modified "2023-09-26" @default.
• W2950759852 title "Polymeric Nanoparticles: A Promising Tool to Enhance the Solubility of Poorly Water Soluble Drug" @default.
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• W2950759852 doi "https://doi.org/10.2174/1574885514666190610125127" @default.
• W2950759852 hasPublicationYear "2020" @default.
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