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- W2950762511 abstract "Targeting the minor groove of DNA through binding to a small molecule has long been considered an important molecular-recognition strategy in biology. A wide range of synthetic heterocyclic molecules bind noncovalently in the minor groove of the double helix and are also effective against a number of human and animal diseases. A classic structural concept, the isohelicity principle, has guided much of this work: such heterocyclic molecules require a shape that complements the convex surface of the minor groove. Researchers have used this principle to design molecules that can read DNA sequences. This principle also predicts that molecules that lack the complementary shape requirement would only bind weakly to DNA. Recently, however, researchers have unexpectedly found that some essentially linear compounds, which do not have this feature, can have high DNA affinity. In this Account, we discuss an alternative recognition concept based on these new findings. We demonstrate that highly structured water molec..." @default.
- W2950762511 created "2019-06-27" @default.
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- W2950762511 date "2009-05-05" @default.
- W2950762511 modified "2023-09-25" @default.
- W2950762511 title "ChemInform Abstract: A Role for Water Molecules in DNA-Ligand Minor Groove Recognition" @default.
- W2950762511 cites W2047110397 @default.
- W2950762511 doi "https://doi.org/10.1002/chin.200918255" @default.
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