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- W2950763935 abstract "Twelve ethoxycarbonyl or phenylsulfonyl derivatives as prodrugs of hydroxylamine or phenylhydroxylamine were prepared and tested for antiplatelet (in vitro, Born test) antithrombotic (in vivo thrombosis model), and antihypertensive (in vivo, SHR rats) effects. In the Born test N,N-bisphenylsulfonylhydroxylamine (10) was most active (IC50 = 11 μmol/L). The N-ethoxycarbonyl-phenylhydroxylamine (7) was the most potent antithrombotic compound. It inhibited the thrombus formation in mesenteric arterioles of rats by 39% after a single p.o. dose of 60 mg/kg. Compound 7 lacked any antihypertensive activity. It, therefore, had been possible to seperate completely the antithrombotic activities from antihypertensive properties in suitable hydroxylamine derivatives." @default.
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- W2950763935 date "1998-11-01" @default.
- W2950763935 modified "2023-09-27" @default.
- W2950763935 title "Hydroxylamine Derivatives" @default.
- W2950763935 doi "https://doi.org/10.1002/(sici)1521-4184(199811)331:11<365::aid-ardp365>3.0.co;2-n" @default.
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