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- W2950768754 abstract "(Biophysical Journal 116, 487–502; February 5, 2019) Eq. 7 in the original publication mistakenly included an inter-leaflet coupling term W=∑i,jσ2(axi,ayj) about which we asserted that it must be equal to 0. In fact, this term should not have been included at all in that equation. The correct form of the equation is:σ2(A)=∑iσ2(axi)+∑iσ2(ayi)2+∑i≠jσ2(axi,axj)+∑i≠jσ2(ayi,ayj)2(7) That W is not 0, but rather equal to σ2(A), is demonstrated below in relation to the correct form of Eq. 7. We note that this correction to Eq. 7 does not affect the derivation that follows from it, and the original results of the publication are unchanged. We thank Prof John Nagle for pointing out the original inconsistency and initiating the discussion about the W term. Quantification of W: Subject to the constraint A=Ax=Ay (where A denotes the bilayer area, and Ax and Ay represent the areas of the two leaflets),σ2(A)=σ2(Ax)=σ2(Ay)=σ2(Ax)+σ2(Ay)2,(1) which after expansion becomes:σ2(A)=∑iσ2(axi)+∑i≠jσ2(axi,axj)+∑iσ2(ayi)+∑i≠jσ2(ayi,ayj)2.(2) Eq. 2 is the same as Eq. 7 above and it does not include W. An alternative way to express σ2(A) is as:σ2(A)=σ2(Ax+Ay2)=∑iσ2(axi)+∑i≠jσ2(axi,axj)+∑iσ2(ayi)+∑i≠jσ2(ayi,ayj)+2W4(3) where W=∑ijσ2(axi,ayj) represents inter-leaflet coupling. However, since Eq. (2) and Eq. (3) are equal, it must be the case that:W=σ2(A)≠0.(4) A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness RevisitedDoktorova et al.Biophysical JournalJanuary 2, 2019In BriefBecause lipid bilayers can bend and stretch in ways similar to thin elastic sheets, physical models of bilayer deformation have utilized mechanical constants such as the moduli for bending rigidity ( κ C ) and area compressibility (KA). However, the use of these models to quantify the energetics of membrane deformation associated with protein-membrane interactions, and the membrane response to stress is often hampered by the shortage of experimental data suitable for the estimation of the mechanical constants of various lipid mixtures. Full-Text PDF Open Archive" @default.
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- W2950768754 title "A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited" @default.
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- W2950768754 doi "https://doi.org/10.1016/j.bpj.2019.07.039" @default.
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