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- W2950769065 abstract "Summary Sensory hair cells in the ear utilize specialized ribbon synapses. These synapses are defined by electron-dense presynaptic structures called ribbons, composed primarily of the structural protein Ribeye. Previous work has shown that voltage-gated influx of Ca 2+ through Ca V 1.3 channels is critical for hair-cell synapse function and can impede ribbon formation. We show that in mature zebrafish hair cells, evoked presynaptic-Ca 2+ influx through Ca V 1.3 channels initiates mitochondrial-Ca 2+ (mito-Ca 2+ ) uptake adjacent to ribbons. Block of mito-Ca 2+ uptake in mature cells depresses presynaptic Ca 2+ influx and impacts synapse integrity. In developing zebrafish hair cells, mito-Ca 2+ uptake coincides with spontaneous rises in presynaptic Ca 2+ influx. Spontaneous mito-Ca 2+ loading lowers cellular NAD + /NADH redox and downregulates ribbon formation. Direct application of NAD + or NADH increases or decreases ribbon formation respectively, possibly acting through the NAD(H)-binding domain on Ribeye. Our results present a mechanism where presynaptic- and mito-Ca 2+ couple to confer proper presynaptic function and formation." @default.
- W2950769065 created "2019-06-27" @default.
- W2950769065 creator A5026777030 @default.
- W2950769065 creator A5030218982 @default.
- W2950769065 creator A5040496147 @default.
- W2950769065 creator A5051747249 @default.
- W2950769065 creator A5066266457 @default.
- W2950769065 creator A5075474558 @default.
- W2950769065 date "2019-06-14" @default.
- W2950769065 modified "2023-09-23" @default.
- W2950769065 title "Synaptic mitochondria are critical for hair-cell synapse formation and function" @default.
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