Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950769745> ?p ?o ?g. }
- W2950769745 abstract "Abstract Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes and lipid species. We performed a review of all genetic association studies, and identified > 800 class-specific metabolite loci that influence metabolite levels. In a twin-family cohort ( N = 5,117), these metabolite loci were leveraged to simultaneously estimate total heritability ( h 2 total ), and the proportion of heritability captured by known metabolite loci ( h 2 Metabolite-hits ) for 309 lipids and 52 organic acids. Our study revealed significant differences in h 2 Metabolite-hits among different classes of lipids and organic acids. Furthermore, phosphatidylcholines with a high degree of unsaturation had higher h 2 Metabolite-hits estimates than phosphatidylcholines with a low degree of unsaturation. This study highlights the importance of common genetic variants for metabolite levels, and elucidates the genetic architecture of metabolite classes and lipid species." @default.
- W2950769745 created "2019-06-27" @default.
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- W2950769745 date "2019-06-14" @default.
- W2950769745 modified "2023-09-27" @default.
- W2950769745 title "The genomic architecture of blood metabolites based on a decade of genome-wide analyses" @default.
- W2950769745 cites W1513618424 @default.
- W2950769745 cites W1915710460 @default.
- W2950769745 cites W1935434993 @default.
- W2950769745 cites W1965493220 @default.
- W2950769745 cites W1981188819 @default.
- W2950769745 cites W1983539381 @default.
- W2950769745 cites W1989968706 @default.
- W2950769745 cites W1993018723 @default.
- W2950769745 cites W1996209745 @default.
- W2950769745 cites W1997062226 @default.
- W2950769745 cites W2032058847 @default.
- W2950769745 cites W2033151532 @default.
- W2950769745 cites W2039671079 @default.
- W2950769745 cites W2039792137 @default.
- W2950769745 cites W2053385401 @default.
- W2950769745 cites W2056903366 @default.
- W2950769745 cites W2061539393 @default.
- W2950769745 cites W2063028213 @default.
- W2950769745 cites W2068509302 @default.
- W2950769745 cites W2093369971 @default.
- W2950769745 cites W2098499808 @default.
- W2950769745 cites W2102213696 @default.
- W2950769745 cites W2104549677 @default.
- W2950769745 cites W2108889957 @default.
- W2950769745 cites W2110808585 @default.
- W2950769745 cites W2112759585 @default.
- W2950769745 cites W2113532105 @default.
- W2950769745 cites W2115098571 @default.
- W2950769745 cites W2122732537 @default.
- W2950769745 cites W2123452207 @default.
- W2950769745 cites W2133112641 @default.
- W2950769745 cites W2138138356 @default.
- W2950769745 cites W2141034208 @default.
- W2950769745 cites W2149777433 @default.
- W2950769745 cites W2155938833 @default.
- W2950769745 cites W2156665896 @default.
- W2950769745 cites W2157752701 @default.
- W2950769745 cites W2161633633 @default.
- W2950769745 cites W2164339823 @default.
- W2950769745 cites W2165681080 @default.
- W2950769745 cites W2166354753 @default.
- W2950769745 cites W2166375564 @default.
- W2950769745 cites W2168990503 @default.
- W2950769745 cites W2169718193 @default.
- W2950769745 cites W2171254004 @default.
- W2950769745 cites W2188707104 @default.
- W2950769745 cites W2270323152 @default.
- W2950769745 cites W2310542696 @default.
- W2950769745 cites W2318079341 @default.
- W2950769745 cites W2320692565 @default.
- W2950769745 cites W2326847038 @default.
- W2950769745 cites W2337831726 @default.
- W2950769745 cites W2413234541 @default.
- W2950769745 cites W2510973425 @default.
- W2950769745 cites W2539494034 @default.
- W2950769745 cites W2586691160 @default.
- W2950769745 cites W2617742891 @default.
- W2950769745 cites W2750825703 @default.
- W2950769745 cites W2767683865 @default.
- W2950769745 cites W2781928680 @default.
- W2950769745 cites W2788593837 @default.
- W2950769745 cites W2897213523 @default.
- W2950769745 cites W2899054073 @default.
- W2950769745 cites W2899070097 @default.
- W2950769745 cites W2899616402 @default.
- W2950769745 cites W2899749109 @default.
- W2950769745 cites W2923424663 @default.
- W2950769745 cites W2924530200 @default.
- W2950769745 cites W2931475264 @default.
- W2950769745 cites W2943669244 @default.
- W2950769745 cites W4232879552 @default.
- W2950769745 cites W4247092709 @default.
- W2950769745 cites W648598527 @default.