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- W2950771981 abstract "Abstract Recent theoretical work suggested that deleterious mutations could accumulate during the range expansion of a species, negatively affecting its fitness. Recent theory predicts that the fitness of pioneer populations can decline when species expand their range, due to high rates of genetic drift on wave fronts making selection less efficient at purging deleterious variants. To test these predictions, we studied the fate of mutator bacteria expanding their range for 1650 generations on agar plates. In agreement with theory, we find that growth abilities of strains with a high mutation rate (HMR lines) decreased significantly over time, unlike strains with a lower mutation rate (LMR lines) that present three to four times fewer mutations. Estimation of the distribution of fitness effect under a spatially explicit model reveals a mean negative effect for new mutations (−0.38%), but it suggests that both advantageous and deleterious mutations have accumulated during the experiment. Furthermore, the fitness of HMR lines measured in different environments has decreased relative to the ancestor strain, whereas that of LMR lines remained unchanged. Contrastingly, strains with a HMR evolving in a well-mixed environment accumulated less mutations than agar-evolved strains and showed an increased fitness relative to the ancestor. Our results suggest that spatially expanding species are affected by deleterious mutations, leading to a drastic impairment of their evolutionary potential." @default.
- W2950771981 created "2019-06-27" @default.
- W2950771981 creator A5006474715 @default.
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- W2950771981 date "2017-08-16" @default.
- W2950771981 modified "2023-10-13" @default.
- W2950771981 title "Accumulation of Deleterious Mutations During Bacterial Range Expansions" @default.
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- W2950771981 doi "https://doi.org/10.1534/genetics.117.300144" @default.
- W2950771981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5629331" @default.