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- W2950777204 abstract "A series of 6-thioxopyrimidines (5, 6), their 6-oxo- analogs (11-14), and pyrimidine-2,4-diones (20-26), were synthesized and evaluated for their antitumoral activity against 60 tumoral cell lines. The activity of propenethioamide (3, 4) and propeneamide (7-10 and 15-19) intermediates is also reported. Among the tested compounds the thioxopyrimidine 5c, bearing an N'-benzyl group, showed the best cytostatic activity. Furthermore, high selectivity and cytotoxic activity on the HOP-92 cell line of non-small cell lung cancer was exhibited by 3-amino-2-[(methylamino)thioxamethyl]-3-pyrrolidino-2-propenenitrile (3a)." @default.
- W2950777204 created "2019-06-27" @default.
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- W2950777204 date "2010-05-22" @default.
- W2950777204 modified "2023-09-25" @default.
- W2950777204 title "ChemInform Abstract: Synthesis and Antitumor Evaluation of 6-Thioxo-, 6-Oxo- and 2,4-Dioxopyrimidine Derivatives." @default.
- W2950777204 cites W2005370864 @default.
- W2950777204 doi "https://doi.org/10.1002/chin.200206171" @default.
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