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• W2950778110 abstract "The efficient generation of complex molecular architectures from simple precursors is one of the most important aspects in the design and development of synthetic methodologies. The chemistry of reactive species generated by the oxidative dearomatization of phenols, such as <i>o</i>-quinone acetals, 6-acetoxycyclohexa-2,4-di­enones, and their congeners, has stimulated widespread interest among organic chemists, and the use of such reactive species has emerged as a powerful method for the efficient synthesis of complex molecules. Our approach to create molecular complexity and diversity involves the oxidative dearomatization of 2-(hydroxymethyl)phenols to give spiro[cyclohexa-2,4-dienone-6,2′-oxiranes], followed by cycloaddition and transformation of the resulting adducts in the ground and excited states. In this account, we describe the evolution of the methodology and its application which has led to the development of novel and efficient routes to a diverse array of complex molecular architectures from simple aromatics. 1 Introduction 2 Cycloaddition of Cyclohexa-2,4-dienones of Types <b>3</b> and <b>4</b> and Manipulation of the Adducts in the Ground and Excited States 2.1 Cycloaddition of Cyclohexa-2,4-dienones of Types <b>3</b> and <b>4</b>: An Efficient Route to Functionalized and Appended Bicyclo[2.2.2]octanes 2.1.1 Cycloaddition of Cyclohexa-2,4-dienones of Types <b>3</b> and <b>4</b> with Electron-Deficient π-Partners 2.1.2 Cycloaddition of Cyclohexadienones of Type <b>4</b> with Vinyl Ethers and Vinyl Acetate 2.1.3 Cycloaddition of Cyclohexadienones of Types <b>3</b> and <b>4</b> with Acyclic 1,3-Dienes: Direct Entry to Bicyclo[2.2.2]octenones Having an <i>endo</i>-Vinyl Group 2.2 Manipulation of the Oxirane Moiety or the Chloromethyl and Hydroxy Groups in the Adducts: Synthesis of Embellished Bicyclo[2.2.2]octanes 2.3 3,3-Sigmatropic Shift in Bicyclo[2.2.2]octanes: A General Stereoselective Route to Functionalized <i>cis</i>-Decalin Derivatives 2.4 Sigmatropic Rearrangements of β,γ-Enones in Excited States: Stereoselective Routes to Bicyclo[3.3.0]- and Bi­cyclo[4.2.0]octanes and Tricyclic Compounds 3 Synthetic Applications 3.1 Synthesis of Hirsutic Acid C and the Framework of ­Pupukeananes from a Common Precursor 3.2 Chemistry of Fused Spiro[cyclohexa-2,4-dienone-6,2′-oxiranes] and Their Adducts: Synthesis of Propellanes and ­Steroid–Polyquinane Hybrids 3.2.1 A General Route to [3.3.3]- and [4.3.3]Propellanes 3.2.2 Synthesis of Steroid–Polyquinane Hybrids 3.3 Synthesis of Tri- and Tetracyclic Networks of Atisane Diterpenoids 3.3.1 Synthesis of Tricyclo[6.2.2.0^1,6]dodecanes and Their Homologues 3.3.2 Synthesis of the Tetracyclic Network of Atisane Diterpenoids: An Interesting Manifestation of Subtle Control by a Remote Functional Group 3.4 Intramolecular Cycloaddition of Cyclohexa-2,4-dienones: Synthesis of Platencin 4 Summary and Outlook" @default.
• W2950778110 created "2019-06-27" @default.
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• W2950778110 date "2013-11-07" @default.
• W2950778110 modified "2023-10-01" @default.
• W2950778110 title "Molecular Complexity and Diversity from Aromatics. The Chemistry of Spiro[cyclohexa-2,4-dienone-6,2′-oxiranes] and Their Congeners: Cycloaddition and Beyond" @default.
• W2950778110 doi "https://doi.org/10.1055/s-0033-1338978" @default.
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