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- W2950781663 abstract "Abstract Repetitive sequences derived from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genome integrity. Repetitive elements are often found in heterochromatin; however, the roles and interactions of heterochromatin proteins in repeat regulation are poorly understood. Here we show that a diverse set of C. elegans heterochromatin proteins act together with the piRNA and nuclear RNAi pathways to silence repetitive elements and prevent genotoxic stress in the germ line. Mutants in genes encoding HPL-2/HP1, LIN-13, LIN-61, LET-418/Mi-2, and H3K9me2 histone methyltransferase MET-2/SETDB1 also show functionally redundant sterility, increased germline apoptosis, DNA repair defects, and interactions with small RNA pathways. Remarkably, fertility of heterochromatin mutants could be partially restored by inhibiting cep-1/p53 , endogenous meiotic double strand breaks, or the expression of MIRAGE1 DNA transposons. Functional redundancy among these factors and pathways underlies the importance of safeguarding the genome through multiple means." @default.
- W2950781663 created "2019-06-27" @default.
- W2950781663 creator A5005451961 @default.
- W2950781663 creator A5012391688 @default.
- W2950781663 creator A5022318807 @default.
- W2950781663 creator A5025484463 @default.
- W2950781663 creator A5032317157 @default.
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- W2950781663 creator A5051464967 @default.
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- W2950781663 creator A5081247356 @default.
- W2950781663 creator A5085407972 @default.
- W2950781663 creator A5087861169 @default.
- W2950781663 date "2017-03-02" @default.
- W2950781663 modified "2023-10-04" @default.
- W2950781663 title "A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress" @default.
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