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- W2950783983 abstract "(-)-Blebbistatin (1), a recently discovered small molecule inhibitor of the ATPase activity of non-muscle myosin II has been prepared from methyl 5-methylanthranilate (6) in three steps. This flexible synthetic route has also been used to prepare a nitro group-containing analogue 12 that has modified fluorescence properties and improved stability under microscope illumination. The key step in the synthesis of 1 and its analogues was the asymmetric hydroxylation of the quinolone intermediate 3 using the Davis oxaziridine methodology. The absolute stereochemistry of (-)-blebbistatin (1) was shown to be S by X-ray crystal structure analysis of a heavy atom (bromine) containing analogue 11, which was subsequently reduced and shown to be identical to 1." @default.
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- W2950783983 date "2005-09-06" @default.
- W2950783983 modified "2023-09-24" @default.
- W2950783983 title "Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (-)-Blebbistatin." @default.
- W2950783983 cites W2065887894 @default.
- W2950783983 doi "https://doi.org/10.1002/chin.200536213" @default.
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