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• W2950784625 abstract "Most new mutations are deleterious and are eventually eliminated by natural selection. But in an adapting population, the rapid amplification of beneficial mutations can hinder the removal of deleterious variants in nearby regions of the genome, altering the patterns of sequence evolution. Here, we analyze the interactions between beneficial driver mutations and linked deleterious passengers during the course of adaptation. We derive analytical expressions for the substitution rate of a deleterious mutation as a function of its fitness cost, as well as the reduction in the beneficial substitution rate due to the genetic load of the passengers. We find that the fate of each deleterious mutation varies dramatically with the rate and spectrum of beneficial mutations, with a non-monotonic dependence on both the population size and the rate of adaptation. By quantifying this dependence, our results allow us to estimate which deleterious mutations will be likely to fix, and how many of these mutations must arise before the progress of adaptation is significantly reduced." @default.
• W2950784625 created "2019-06-27" @default.
• W2950784625 creator A5051640845 @default.
• W2950784625 creator A5069948947 @default.
• W2950784625 date "2014-05-15" @default.
• W2950784625 modified "2023-09-27" @default.
• W2950784625 title "Deleterious passengers in adapting populations" @default.
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• W2950784625 hasPublicationYear "2014" @default.
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